Cell delivery and tracking in post-myocardial infarction cardiac stem cell therapy: an introduction for clinical researchers.
Stem cell-based therapy for patients with post-infarct heart failure is a relatively new and revolutionary concept in cardiology. Despite the encouraging results from pre-clinical studies, outcomes from most clinical trials remain moderately positive while the clinical benefits are largely attribute...
| Publicado en: | Heart Failure Reviews Vol. 15; no. 1; pp. 1 - 15 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Jan2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105284142&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105284142 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13824147 OG1 jtl: Heart Failure Reviews issn: 13824147 maglogo: N pubinfo: dt: Jan2010 vid: 15 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105284142 NLM19238541 2010526655 10.1007/s10741-009-9134-1 NLM19238541 105284142 ppf: 1 ppct: 14 formats: tig: atl: Cell delivery and tracking in post-myocardial infarction cardiac stem cell therapy: an introduction for clinical researchers. aug: au: Wei H Ooi TH Tan G Lim SY Qian L Wong P Shim W Wei, Heming Ooi, Ting Huay Tan, Genevieve Lim, Sze Yun Qian, Ling Wong, Philip Shim, Winston affil: Research and Development Unit, National Heart Centre of Singapore, Singapore, Singapore sug: subj: Cell Transplantation Heart Failure Therapy Monitoring, Physiologic Myocardium Animals Clinical Trials Heart Failure Etiology Heart Failure Physiopathology Infusions, Intravenous Methods Injections, Intralesional Equipment and Supplies Injections, Intralesional Methods Isotopes Magnetic Resonance Imaging Medical Practice, Evidence-Based Microscopy Myocardial Infarction Complications Myocardial Infarction Surgery Stem Cells Transplantation Tomography, Emission-Computed Tomography, Emission-Computed, Single-Photon Treatment Outcomes ab: Stem cell-based therapy for patients with post-infarct heart failure is a relatively new and revolutionary concept in cardiology. Despite the encouraging results from pre-clinical studies, outcomes from most clinical trials remain moderately positive while the clinical benefits are largely attributed to transplanted cell-associated paracrine effects in stimulating angiogenesis and protecting endogenous cardiomyocytes. This scenario indicates that there may be a considerably protracted iterative process of conceptual and procedural refinement before true clinical benefits can be fully materialized. At present, many pressing questions regarding cell therapy remain unanswered. In addition to the primary interest in determining the ideal type of stem cells with best cardiogenic potential in vitro and in vivo, there are growing concerns on the impact of the host cardiac milieu on the transplanted cells, including their survival, migration, engraftment, and trans-differentiation as well as contribution to left ventricular function. Effective cell delivery and tracking methods are central to the unraveling of these questions. To date, cell-delivery modalities are yet to be optimized and strategies for safe and effective assessment of cells transplanted in the recipients are to be established. In this review, we discuss cell delivery and tracking modalities that are adopted in the current pre-clinical and clinical studies. We further discussed emerging technologies that are poised to impact the success of cell therapy. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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