Monitoring of treatment response after chemoradiotherapy for head and neck cancer using in vivo 1H MR spectroscopy.
Elevated choline (Cho) level has been documented on proton magnetic resonance spectroscopy ((1)H MRS) in head and neck squamous cell carcinoma and therefore percentage changes in Cho levels after chemoradiotherapy may serve as a marker of residual cancer in a post-treatment mass (PTM). Forty-six pat...
| Publicado en: | European Radiology Vol. 20; no. 1; pp. 165 - 173 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105285605&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105285605 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2010 vid: 20 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105285605 47410914 NLM19652977 2010528180 10.1007/s00330-009-1531-2 NLM19652977 105285605 ppf: 165 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Monitoring of treatment response after chemoradiotherapy for head and neck cancer using in vivo 1H MR spectroscopy. aug: au: King AD Yeung DK Yu KH Mo FK Hu CW Bhatia KS Tse GM Vlantis AC Wong JK Ahuja AT King, Ann D Yeung, David K W Yu, Kwok-Hung Mo, Frankie K F Hu, Chen-Wen Bhatia, Kunwar S Tse, Gary M K Vlantis, Alexander C Wong, Jeffrey K T Ahuja, Anil T affil: Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong SAR, China sug: subj: Choline Analysis Head and Neck Neoplasms Diagnosis Head and Neck Neoplasms Therapy Magnetic Resonance Spectroscopy Methods Protons Diagnostic Use Tumor Markers, Biological Analysis Chemotherapy, Adjuvant Diagnosis, Computer Assisted Methods Female Head and Neck Neoplasms Metabolism Human Male Prognosis Radiotherapy, Adjuvant Reproducibility of Results Sensitivity and Specificity Treatment Outcomes Female Male ab: Elevated choline (Cho) level has been documented on proton magnetic resonance spectroscopy ((1)H MRS) in head and neck squamous cell carcinoma and therefore percentage changes in Cho levels after chemoradiotherapy may serve as a marker of residual cancer in a post-treatment mass (PTM). Forty-six patients underwent (1)H MRS before treatment and the 30 patients with a PTM underwent repeat (1)H MRS at 6 weeks post-treatment. The percentage change in Cho/creatine and Cho/water ratios were correlated with residual cancer. The mean pretreatment Cho/creatine and Cho/water ratios were 2.24 and 1.20 x 10(-3), respectively. Cho persisted in four out of nine PTMs with residual cancer. Cho was absent in five out of nine PTMs with residual cancer and 21/21 PTMs without cancer. The number of PTMs with persistent Cho was too small to allow analysis of percentage change in ratios but the presence of Cho in a PTM showed significant correlation with residual cancer (p = 0.0046), producing a sensitivity, specificity, positive predictive value and negative predictive value of 44%, 100%, 100% and 81%, respectively. Therefore, the presence of Cho in a PTM may serve as a marker of residual cancer. Furthermore since so few PTMs contain Cho, a percentage change in Cho ratios may not be a useful method for monitoring treatment response. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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