The effect of epigallocatechin-3-gallate, a constituent of green tea, on transforming growth factor-ß1-stimulated wound contraction.
Dermal fibrosis, or scarring, following surgical incisions, traumatic wounds and burns presents a major clinical burden. Transforming growth factor (TGF)-ß1 is a major factor known to stimulate fibroblast proliferation, collagen production, and the differentiation of fibroblast to myofibroblast prom...
| Publicado en: | Wound Repair & Regeneration Vol. 18; no. 1; pp. 80 - 89 |
|---|---|
| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan/Feb2010
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105286567&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105286567 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Jan/Feb2010 vid: 18 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105286567 105286567 2010529210 10.1111/j.1524-475X.2009.00552.x 105286567 ppf: 80 ppct: 9 formats: fmt: @attributes: type: P tig: atl: The effect of epigallocatechin-3-gallate, a constituent of green tea, on transforming growth factor-ß1-stimulated wound contraction. aug: au: Klass BR Branford OA Grobbelaar AO Rolfe KJ affil: The RAFT Institute, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom sug: subj: Cicatrix Physiopathology Flavonoids Therapeutic Use Green Tea Growth Substances Drug Effects Analysis of Variance Burns Complications Cicatrix Complications Collagen Physiology Data Analysis Software Enzymes Analysis Fibroblasts Physiology Funding Source Human In Vitro Studies Models, Statistical Polymerase Chain Reaction Surgical Wound Complications T-Tests Tissue Culture Techniques Wounds and Injuries Complications ab: Dermal fibrosis, or scarring, following surgical incisions, traumatic wounds and burns presents a major clinical burden. Transforming growth factor (TGF)-ß1 is a major factor known to stimulate fibroblast proliferation, collagen production, and the differentiation of fibroblast to myofibroblast promoting wound contraction. Furthermore, excessive or prolonged TGF-ß1 has been shown to be associated with scarring. Green tea contains high amounts of polyphenols with the major polyphenolic compound being epigallocatechin-3-gallate (EGCG). EGCG has been shown to be anti-inflammatory, anti-oxidant, and may improve wound healing and scarring, though its precise effect on TGF-ß1 remains unclear. This study aimed at determining the effect of EGCG on TGF-ß1 collagen contraction, gene expression and the differentiation of fibroblast to myofibroblast. EGCG appears to affect the role that TGF-ß1 plays in fibroblast populated collagen gel contraction and this seems to be through bothmyofibroblast differentiation and connective tissue growth factor gene expression and reduces the expression of collagen type I gene regulation. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|