An in silico approach to the analysis of acute wound healing.
The complex interactions that characterize acute wound healing have stymied the development of effective therapeutic modalities. The use of computational models holds the promise to improve our basic approach to understanding the process. By modifying an existing ordinary differential equation model...
| Publicado en: | Wound Repair & Regeneration Vol. 18; no. 1; pp. 105 - 114 |
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| Autores principales: | , , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan/Feb2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105286575&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105286575 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Jan/Feb2010 vid: 18 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105286575 2010529219 10.1111/j.1524-475X.2009.00549.x 105286575 ppf: 105 ppct: 9 formats: fmt: @attributes: type: P tig: atl: An in silico approach to the analysis of acute wound healing. aug: au: Menke NB Cain JW Reynolds A Chan DM Segal RA Witten TM Bonchev DG Diegelmann RF Ward KR affil: Department of Emergency Medicine, Virginia Commonwealth University, Richmond, Virginia sug: subj: Wound Healing Evaluation Bacterial Infections Physiopathology Bioinformatics Computer Simulation Fibroblasts Physiology Funding Source Inflammation Physiopathology Models, Statistical Oxygenation Wound Healing Physiology Wounds and Injuries Physiopathology ab: The complex interactions that characterize acute wound healing have stymied the development of effective therapeutic modalities. The use of computational models holds the promise to improve our basic approach to understanding the process. By modifying an existing ordinary differential equation model of systemic inflammation to simulate local wound healing, we expect to improve the understanding of the underlying complexities of wound healing and thus allow for the development of novel, targeted therapeutic strategies. The modifications in this local acute wound healing model include: evolution from a systemic model to a local model, the incorporation of fibroblast activity, and the effects of tissue oxygenation. Using these modifications we are able to simulate impaired wound healing in hypoxic wounds with varying levels of contamination. Possible therapeutic targets, such as fibroblast death rate and rate of fibroblast recruitment, have been identified by computational analysis. This model is a step toward constructing an integrative systems biology model of human wound healing. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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