Refractory polyarticular gouty arthritis as a manifestation of immune reconstitution inflammatory syndrome.
Immune reconstitution inflammatory syndrome (IRIS) describes the initial clinical deterioration some patients manifest upon initiation of effective antiretroviral therapy (ART) for HIV infection. In this report we describe a case of IRIS manifesting as polyarticular gout, a previously unreported rhe...
| Published in: | JRC: Journal of Clinical Rheumatology Vol. 16; no. 1; pp. 40 - 43 |
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| Main Authors: | , , , , |
| Format: | case study Journal Article |
| Published: |
Lippincott Williams & Wilkins
2010 Jan
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105295081&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105295081 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10761608 N16 jtl: JRC: Journal of Clinical Rheumatology issn: 10761608 maglogo: N pubinfo: dt: 2010 Jan vid: 16 iid: 1 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105295081 105295081 2010538712 10.1097/RHU.0b013e3181c78ddc NLM20051757 105295081 ppf: 40 ppct: 3 formats: tig: atl: Refractory polyarticular gouty arthritis as a manifestation of immune reconstitution inflammatory syndrome. aug: au: Sebeny PJ Keith MP Love KM Dwyer TX Ganesan A affil: Division of Infectious Diseases, National Naval Medical Center, Bethesda, MD 20889 sug: subj: Comorbidity Gout Etiology HIV Infections Complications Immune Reconstitution Inflammatory Syndrome Diagnosis Immune Reconstitution Inflammatory Syndrome Symptoms Antiviral Agents CD4 Lymphocyte Count Immune Reconstitution Inflammatory Syndrome Complications Immune System Physiopathology Male Middle Age Viral Load Middle Aged: 45-64 years Male ab: Immune reconstitution inflammatory syndrome (IRIS) describes the initial clinical deterioration some patients manifest upon initiation of effective antiretroviral therapy (ART) for HIV infection. In this report we describe a case of IRIS manifesting as polyarticular gout, a previously unreported rheumatological manifestation of IRIS. A 53-year-old HIV-infected man with a history of intermittent attacks of gout and an initial CD4 count of 112 cells/microL and a viral load of >100,000 copies/mL presented to our institution with severe, refractory, polyarticular gout approximately 4 weeks after initiating ART. At this point, the patient demonstrated significant gains in his CD4 counts (103 cells/microL) and a greater than 3 log decline in his HIV-1- viral load. This episode was prolonged lasting for approximately 10 weeks and required hospitalization for the management of pain and control of inflammation. The temporal associations of this attack with the initiation of ART and the observed immunologic reconstitution make IRIS a clinical possibility.Monosodium urate crystals through their interactions with interleukin 1- beta, and neutrophilic synovitis play a critical role in the pathophysiology of gout. Defects in both neutrophil and macrophage function and imbalances in the cytokine milieu are documented in HIV infected patients. The introduction of ART results in restoration of neutrophil and macrophage function, declines in levels of the anti-inflammatory cytokine IL-10, and increases in levels of proinflammatory cytokines including IL-1 beta, which may provide the necessary milieu for the precipitation of attacks of severe polyarticular gout in the context of ART initiation. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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