Increased white matter gyral depth in dyslexia: implications for corticocortical connectivity.
Recent studies provide credence to the minicolumnar origin of several developmental conditions, including dyslexia. Characteristics of minicolumnopathies include abnormalities in how the cortex expands and folds. This study examines the depth of the gyral white matter measured in an MRI series of 15...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 40; no. 1; pp. 21 - 30 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105296186&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105296186 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jan2010 vid: 40 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105296186 2010540039 10.1007/s10803-009-0817-1 NLM19609661 105296186 ppf: 21 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Increased white matter gyral depth in dyslexia: implications for corticocortical connectivity. aug: au: Casanova MF El-Baz AS Giedd J Rumsey JM Switala AE affil: Department of Biomedical Engineering, University of Louisville, Louisville USA sug: subj: Brain Anatomy and Histology Brain Physiopathology Dyslexia Physiopathology Adolescence Adult Confidence Intervals Descriptive Statistics Diagnosis, Laboratory Funding Source Human Intelligence Tests Interview Guides Magnetic Resonance Imaging Male Matched Case Control Psychological Tests Questionnaires Scales Self Report Semi-Structured Interview T-Tests Telencephalon Anatomy and Histology Telencephalon Physiopathology Wechsler Adult Intelligence Scale-Revised Adolescent: 13-18 years Adult: 19-44 years Male ab: Recent studies provide credence to the minicolumnar origin of several developmental conditions, including dyslexia. Characteristics of minicolumnopathies include abnormalities in how the cortex expands and folds. This study examines the depth of the gyral white matter measured in an MRI series of 15 dyslexic adult men and eleven age-matched comparison subjects. Measurements were based upon the 3D Euclidean distance map inside the segmented cerebral white matter surface. Mean gyral white matter depth was 3.05 mm (SD ± 0.30 mm) in dyslexic subjects and 1.63 mm (SD ± 0.15 mm) in the controls. The results add credence to the growing literature suggesting that the attained reading circuit in dyslexia is abnormal because it is inefficient. Otherwise the anatomical substratum (i.e., corticocortical connectivity) underlying this inefficient circuit is normal. A deficit in very short-range connectivity (e.g., angular gyrus, striate cortex), consistent with results of a larger gyral window, could help explain reading difficulties in patients with dyslexia. The structural findings hereby reported are diametrically opposed to those reported for autism. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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