Contrast-enhanced computed tomography for the diagnosis of fatty liver: prospective study with same-day biopsy used as the reference standard.
Purpose: The study purpose was to prospectively determine the accuracy of contrast-enhanced CT in diagnosing fatty liver using same-day biopsy as the reference standard.Materials and Methods: One hundred seventy-nine potential living liver donors underwent unenhanced and portal-phase contrast-enhanc...
| Publicado en: | European Radiology Vol. 20; no. 2; pp. 359 - 367 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105313753&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105313753 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2010 vid: 20 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105313753 47799947 NLM19727755 2010560105 10.1007/s00330-009-1560-x NLM19727755 105313753 ppf: 359 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Contrast-enhanced computed tomography for the diagnosis of fatty liver: prospective study with same-day biopsy used as the reference standard. aug: au: Kim DY Park SH Lee SS Kim HJ Kim SY Kim MY Lee Y Kim TK Khalili K Bae MH Lee JY Lee SG Yu ES Kim, Dae Yoon Park, Seong Ho Lee, Seung Soo Kim, Hye Jin Kim, So Yeon Kim, Min-Young Lee, Yedaun affil: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-2dong, Songpa-gu, Seoul 138-736, Korea sug: subj: Fatty Liver Pathology Fatty Liver Radiography Growth Substances Radiographic Image Enhancement Methods Tomography, X-Ray Computed Methods Adult Biopsy Contrast Media Female Human Growth Substances Diagnostic Use Male Weights and Measures Reproducibility of Results Sensitivity and Specificity Adult: 19-44 years Female Male ab: Purpose: The study purpose was to prospectively determine the accuracy of contrast-enhanced CT in diagnosing fatty liver using same-day biopsy as the reference standard.Materials and Methods: One hundred seventy-nine potential living liver donors underwent unenhanced and portal-phase contrast-enhanced hepatic CT and subsequent liver biopsy on the same day. Attenuation difference between the liver and the spleen on unenhanced (( pre ) L-S) and contrast-enhanced (( post ) L-S) images and blood-subtracted hepatic attenuation on contrast-enhanced images (( post ) L-B), calculated by [L - 0.3 x (0.75 x P + 0.25 x A)]/0.7 where L, P and A represent the attenuation of the liver, main portal vein and abdominal aorta, respectively, were obtained. The accuracy of these indices in diagnosing fatty liver according to various threshold levels, 5%-30% histological steatosis in increments of 5%, was compared using ROC analysis.Results: The area under the ROC curve for ( pre ) L-S, ( post ) L-S and ( post ) L-B was 0.663-0.918, 0.712-0.847 and 0.821-0.923, respectively, depending on the threshold levels of hepatic steatosis. The accuracy of ( pre ) L-S and ( post ) L-S did not differ (P >or= 0.054), despite a trend towards a lower accuracy with ( post ) L-S. ( post ) L-B yielded higher accuracy than ( pre ) L-S at threshold levels of 5% and 10% (P <or= 0.002) and similar accuracy to ( pre ) L-S at the other threshold levels (P >or= 0.144).Conclusion: Portal-phase contrast-enhanced CT has a similar, or even greater, accuracy than unenhanced CT in diagnosing fatty liver. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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