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Abnormal transient pupillary light reflex in individuals with autism spectrum disorders.

Computerized binocular infrared pupillography was used to measure the transient pupillary light reflex (PLR) in both children with autism spectrum disorders (ASDs) and children with typical development. We found that participants with ASDs showed significantly longer PLR latency, smaller constrictio...

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Publicado en:Journal of Autism & Developmental Disorders Vol. 39; no. 11; pp. 1499 - 1509
Autores principales: Fan X, Miles JH, Takahashi N, Yao G
Formato: research tables/charts Journal Article
Publicado: Springer Nature Nov2009
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Nov2009
      vid: 39
      iid: 11
      pid: 237
      pub: Springer Nature
      place: New York, New York
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        2010442691
        10.1007/s10803-009-0767-7
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        atl: Abnormal transient pupillary light reflex in individuals with autism spectrum disorders.
      aug:
        au:
          Fan X
          Miles JH
          Takahashi N
          Yao G
        affil: Department of Biological Engineering, University of Missouri-Columbia, Columbia, MO 65211, USA.
      sug:
        subj:
          Autism Spectrum Disorder Physiopathology
          Reflex, Pupillary Physiology
          Adolescence
          Adult
          Analysis of Variance
          Biological Markers
          Child
          Data Analysis Software
          Descriptive Statistics
          Female
          Fish
          Funding Source
          Interview Guides
          Male
          Missouri
          P-Value
          Post Hoc Analysis
          Psychological Tests
          Repeated Measures
          Scales
          T-Tests
          Human
          Adolescent: 13-18 years
          Adult: 19-44 years
          Child: 6-12 years
          Female
          Male
      ab: Computerized binocular infrared pupillography was used to measure the transient pupillary light reflex (PLR) in both children with autism spectrum disorders (ASDs) and children with typical development. We found that participants with ASDs showed significantly longer PLR latency, smaller constriction amplitude and lower constriction velocity than children with typical development. The PLR latency alone can be used to discriminate the ASD group from the control group with a cross-validated success rate of 89.6%. By adding the constriction amplitude, the percentage of correct classification can be further improved to 92.5%. In addition, the right-lateralization of contraction anisocoria that was observed in participants with typical development was not observed in those with ASDs. Further studies are necessary to understand the origin and implications of these observations. It is anticipated that as potential biomarkers, these pupillary light reflex measurements will advance our understanding of neurodevelopmental differences in the autism brain.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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