Detection of cervical intraepithelial neoplasias and cancers in cervical tissue by in vivo light scattering.
OBJECTIVE: To examine the utility of in vivo elastic light scattering measurements to identify cervical intraepithelial neoplasias (CIN) 2/3 and cancers in women undergoing colposcopy and to determine the effects of patient characteristics such as menstrual status on the elastic light scattering spe...
| Publicado en: | Journal of Lower Genital Tract Disease Vol. 13; no. 4; pp. 216 - 224 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Oct2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105331117&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105331117 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10892591 FR5 jtl: Journal of Lower Genital Tract Disease issn: 10892591 maglogo: N pubinfo: dt: Oct2009 vid: 13 iid: 4 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105331117 105331117 NLM20694193 2010447381 NLM20694193 105331117 ppf: 216 ppct: 8 formats: tig: atl: Detection of cervical intraepithelial neoplasias and cancers in cervical tissue by in vivo light scattering. aug: au: Mourant JR Bocklage TJ Powers TM Greene HM Dorin MH Waxman AG Zsemlye MM Smith HO Mourant, Judith R Bocklage, Thérese J Powers, Tamara M Greene, Heather M Dorin, Maxine H Waxman, Alan G Zsemlye, Meggan M Smith, Harriet O affil: Bioscience Division, Los Alamos National Laboratory, PO Box 1663, MS E535, Los Alamos, New Mexico, 87545 sug: subj: Cervical Intraepithelial Neoplasia Diagnosis Fiber Optics Light Academic Medical Centers Age Factors Cervix Confidence Intervals Female Funding Source Hemoglobins Analysis In Vivo Studies Menopause Menstrual Cycle New Mexico Predictive Value of Tests Sensitivity and Specificity Spectrum Analysis T-Tests Human Female ab: OBJECTIVE: To examine the utility of in vivo elastic light scattering measurements to identify cervical intraepithelial neoplasias (CIN) 2/3 and cancers in women undergoing colposcopy and to determine the effects of patient characteristics such as menstrual status on the elastic light scattering spectroscopic measurements. MATERIALS AND METHODS: A fiber optic probe was used to measure light transport in the cervical epithelium of patients undergoing colposcopy. Spectroscopic results from 151 patients were compared with histopathology of the measured and biopsied sites. A method of classifying the measured sites into two clinically relevant categories was developed and tested using five-fold cross-validation. RESULTS: Statistically significant effects by age at diagnosis, menopausal status, timing of the menstrual cycle, and oral contraceptive use were identified, and adjustments based upon these measurements were incorporated in the classification algorithm. A sensitivity of 77±5% and a specificity of 62±2% were obtained for separating CIN 2/3 and cancer from other pathologies and normal tissue. CONCLUSIONS: The effects of both menstrual status and age should be taken into account in the algorithm for classifying tissue sites based on elastic light scattering spectroscopy. When this is done, elastic light scattering spectroscopy shows good potential for real-time diagnosis of cervical tissue at colposcopy. Guiding biopsy location is one potential near-term clinical application area, while facilitating "see and treat" protocols is a longer term goal. Improvements in accuracy are essential. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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