Topographic features retained after antibiotic modification of Ti alloy surfaces: retention of topography with attachment of antibiotics.
Periprosthetic infection is increasingly prevalent in orthopaedics with infection rates of 2% to 15% after total hip arthroplasty. To effectively decrease bacterial attachment, colonization, and subsequent development of periprosthetic infection, we previously described a method to covalently bond v...
| Publicado en: | Clinical Orthopaedics & Related Research® Vol. 467; no. 7; pp. 1678 - 1688 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Jul2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105349363&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105349363 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0009921X 23N jtl: Clinical Orthopaedics & Related Research® issn: 0009921X maglogo: N pubinfo: dt: Jul2009 vid: 467 iid: 7 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105349363 105349363 NLM19365697 2010305892 10.1007/s11999-009-0828-4 NLM19365697 PMC2690762 105349363 ppf: 1678 ppct: 10 formats: tig: atl: Topographic features retained after antibiotic modification of Ti alloy surfaces: retention of topography with attachment of antibiotics. aug: au: Ketonis C Parvizi J Adams CS Shapiro IM Hickok NJ Ketonis, Constantinos Parvizi, Javad Adams, Christopher S Shapiro, Irving M Hickok, Noreen J affil: Department of Orthopedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA sug: subj: Antibiotics Materials Testing Orthopedic Surgery Prosthesis-Related Infections Prevention and Control Titanium Vancomycin Bacterial Physiology Drug Effects Chemistry, Physical Heat Hydrogen Peroxide Microscopy, Electron, Scanning Oxidation-Reduction Staphylococcus Aureus Drug Effects Staphylococcus Aureus Sulfuric Acids ab: Periprosthetic infection is increasingly prevalent in orthopaedics with infection rates of 2% to 15% after total hip arthroplasty. To effectively decrease bacterial attachment, colonization, and subsequent development of periprosthetic infection, we previously described a method to covalently bond vancomycin to smooth Ti alloy surfaces. To attach vancomycin, the Ti surface is first passivated to create a fresh oxide layer. Previously, passivation has been achieved with an H2SO4/H2O2 etch that can destroy the topography of the underlying implant. Passivation by hydrothermal aging as well as by H2SO4/H2O2 incubation produced a robust oxide layer, but only hydrothermal aging left the geometry unaltered. These hydrothermally passivated Kirschner wires and smooth or beaded Ti surfaces were chemically coupled with vancomycin. Antibiotic-coupled samples representing all three geometries were uniformly covered with antibiotic, resisted colonization by Staphylococcus aureus for longer than 8 hours, and retained their biocompatibility as assessed by normal attachment and morphology of preosteocytic MLO-A5 cells. Using this technique, we believe it is possible to passivate many complex implant designs/geometries as a first step toward covalent bonding of antibiotics or other bioactive factors. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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