Efficacy of a 7-day course of furazolidone, levofloxacin, and lansoprazole after failed Helicobacter pylori eradication.
Background: Increasing resistance to clarithromycin and nitroimidazole is the main cause of failure in the Helicobacter pylori eradication. The ideal retreatment regimen remains unclear, especially in developing countries, where the infection presents high prevalence and resistance to antibiotics. T...
| Publicado en: | BMC Gastroenterology Vol. 9; pp. 38 - 39 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
BioMed Central
2009
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105354343&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105354343 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2009 vid: 9 pid: 24147 pub: BioMed Central artinfo: ui: 105354343 NLM19470177 2010312496 10.1186/1471-230X-9-38 NLM19470177 105354343 ppf: 38 ppct: 1 formats: tig: atl: Efficacy of a 7-day course of furazolidone, levofloxacin, and lansoprazole after failed Helicobacter pylori eradication. aug: au: Eisig JN Silva FM Barbuti RC Rodriguez TN Malfertheiner P Moraes Filho JP Zaterka S Eisig, Jaime N Silva, Fernando M Barbuti, Ricardo C Rodriguez, Tomás Navarro Malfertheiner, Peter Moraes Filho, Joaquim P P Zaterka, Schlioma affil: Serviço de Gastroenterologia Clínica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil sug: subj: Antiinfective Agents Therapeutic Use Helicobacter Infections Drug Therapy Helicobacter Pylori Nitrofurans Therapeutic Use Ofloxacin Therapeutic Use Sulfur Compounds Therapeutic Use Adult Aged Antiinfective Agents Adverse Effects Clinical Trials Dose-Response Relationship, Drug Drug Resistance, Microbial Drug Therapy, Combination Female Male Middle Age Nitrofurans Adverse Effects Ofloxacin Adverse Effects Prospective Studies Salvage Therapy Sulfur Compounds Adverse Effects Treatment Outcomes Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: Increasing resistance to clarithromycin and nitroimidazole is the main cause of failure in the Helicobacter pylori eradication. The ideal retreatment regimen remains unclear, especially in developing countries, where the infection presents high prevalence and resistance to antibiotics. The study aimed at determining the efficacy, compliance and adverse effects of a regimen that included furazolidone, levofloxacin and lansoprazole in patients with persistent Helicobacter pylori infection, who had failed to respond to at least one prior eradication treatment regimen.Methods: This study included 48 patients with peptic ulcer disease. Helicobacter pylori infection was confirmed by a rapid urease test and histological examination of samples obtained from the antrum and corpus during endoscopy. The eradication therapy consisted of a 7-day twice daily oral administration of lansoprazole 30 mg, furazolidone 200 mg and levofloxacin 250 mg. Therapeutic success was confirmed by a negative rapid urease test, histological examination and 14C- urea breath test, performed 12 weeks after treatment completion. The Chi-square method was used for comparisons among eradication rates, previous treatments and previous furazolidone use.Results: Only one of the 48 patients failed to take all medications, which was due to adverse effects (vomiting). Per-protocol and intention-to-treat eradication rates were 89% (95% CI- 89%-99%) and 88% (88-92%), respectively. Mild and moderate adverse effects were reported by 41 patients (85%). For patients with one previous treatment failure, the eradication rate was 100%. Compared to furazolidone-naïve patients, eradication rates were lower in those who had failed prior furazolidone-containing regimen(s) (74% vs. 100%, p = 0.002).Conclusion: An empiric salvage-regimen including levofloxacin, furazolidone and lansoprazole is very effective in the eradication of Helicobacter pylori, particularly in patients that have failed one prior eradication therapy. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|