Gender differences in the effect of auditory stimuli on ventricular repolarization in healthy subjects.
Introduction: Gender differences in the incidence of ventricular arrhythmias have been reported and torsade de pointes associated with long-QT syndrome (LQTS) is more common in women than men. Although auditory stimulation has been recognized as an important trigger of torsade de pointes in LQT2 pat...
| Publicado en: | Journal of Cardiovascular Electrophysiology Vol. 20; no. 6; pp. 653 - 658 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts tracings Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105355603&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105355603 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Jun2009 vid: 20 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105355603 2010313793 10.1111/j.1540-8167.2008.01401.x NLM19207777 105355603 ppf: 653 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Gender differences in the effect of auditory stimuli on ventricular repolarization in healthy subjects. aug: au: Nakagawa M Sekine Y Ono M Taniguchi Y Takahashi N Yonemochi H Saikawa T affil: Division of Laboratory Medicine, Department of Cardiovascular Science, Oita University, School of Medicine, Yufu-city, Oita, Japan sug: subj: Acoustic Stimulation Arrhythmia, Ventricular Heart Ventricle, Left Sex Factors Sympathetic Nervous System Analysis of Variance Demography Electrocardiography Electrocardiography, Ambulatory Equipment and Supplies Fisher's Exact Test Japan Radiography, Thoracic Human ab: Introduction: Gender differences in the incidence of ventricular arrhythmias have been reported and torsade de pointes associated with long-QT syndrome (LQTS) is more common in women than men. Although auditory stimulation has been recognized as an important trigger of torsade de pointes in LQT2 patients, the normal response and gender differences in ventricular repolarization induced by auditory stimuli remained to be evaluated systematically. Methods: Holter ECGs were recorded in 30 healthy volunteers (14 men aged 25 ± 4 years and 16 women aged 23 ± 2 years). They were awakened by an alarm clock at 5:00 am. The RR and QT (QTc) intervals and the T-wave amplitude were measured before and after alarm ringing. Results: The morphology of the T-wave changed dynamically and transiently during awakening. The RR interval significantly decreased just after sounding of the alarm in both sexes (P < 0.0001). The QT interval changed little after the alarm ringing and was significantly longer in women than men (P < 0.0001). The QTc intervals were significantly prolonged just after alarm ringing in both sexes (P < 0.0001); QTc prolongation was significantly longer and more sustained in women than men (P < 0.0001). The T-wave amplitude decreased after the alarm and was significantly lower in women than men (P = 0.0001). Conclusion: Auditory stimulation abruptly and abnormally modulated the dynamics of ventricular repolarization in healthy subjects; the effect was more pronounced in women than men. This gender difference may partially account for the increased susceptibility of women with electrically unstable hearts to arrhythmogenesis. pubtype: Academic Journal doctype: research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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