Frequency analysis of atrial electrograms identifies conduction pathways from the left to the right atrium during atrial fibrillation - studies in two canine models.
Studies of atrial fibrillation (AF) have demonstrated that a stable rhythm of very short cycle length in the left atrium (LA) can cause fibrillatory conduction in the rest of the atria. We tested the hypothesis that fast Fourier transform (FFT) analysis of atrial electrograms (AEGs) during this AF w...
| Published in: | Journal of Cardiovascular Electrophysiology Vol. 20; no. 6; pp. 667 - 675 |
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| Main Authors: | , , , , |
| Format: | research tables/charts tracings Journal Article |
| Published: |
Wiley-Blackwell
Jun2009
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105355609&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105355609 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Jun2009 vid: 20 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105355609 105355609 2010313798 10.1111/j.1540-8167.2008.01403.x NLM19207775 105355609 ppf: 667 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Frequency analysis of atrial electrograms identifies conduction pathways from the left to the right atrium during atrial fibrillation - studies in two canine models. aug: au: Ryu K Sahadevan J Khrestian CM Stambler BS Waldo AL affil: Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA sug: subj: Atrial Fibrillation Electrophysiology Animal Studies Dogs Electrocardiography Funding Source Ohio ab: Studies of atrial fibrillation (AF) have demonstrated that a stable rhythm of very short cycle length in the left atrium (LA) can cause fibrillatory conduction in the rest of the atria. We tested the hypothesis that fast Fourier transform (FFT) analysis of atrial electrograms (AEGs) during this AF will rapidly and reliably identify LA-to-right atrium (RA) conduction pathway(s) generated by the driver. Methods and Results: During induced atrial tachyarrhythmias in the canine sterile pericarditis and rapid ventricular pacing-induced congestive heart failure models, 380-404 AEGs were recorded simultaneously from epicardial electrodes on both atria. FFT analysis of AEGs during AF demonstrated a dominant frequency peak in the LA (driver), and multiple frequency peaks in parts of the LA and the most of the RA. Conduction pathways from the LA driver to the RA varied from study-to-study. They were identified by the presence of multiple frequency peaks with one of the frequency peaks at the same frequency as the driver, and traveled (1) inferior to the inferior vena cava (IVC); (2) between the superior vena cava and the right superior pulmonary vein (RSPV); (3) between the RSPV and the right inferior pulmonary vein (RIPV); (4) between the RIPV and the IVC; and (5) via Bachmann's bundle. Conduction pathways identified by FFT analysis corresponded to the conduction pathways found in classical sequence of activation mapping. Computation time for FFT analysis for each AF episode took less than 5 minutes. Conclusion: FFT analysis allowed rapid and reliable detection of the LA-to-RA conduction pathways in AF generated by a stable and rapid LA driver. pubtype: Academic Journal doctype: research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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