MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy: preliminary evidence.
Conclusions: Our very preliminary results support the hypothesis that MASPIN expression in primary head and neck squamous cell carcinoma (HNSCC) may be a valuable parameter for predicting patients' responses to a treatment based on carboplatin plus vinorelbine combined with radiotherapy. Objectives:...
| Publicado en: | Acta Oto-Laryngologica Vol. 129; no. 7; pp. 786 - 793 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jul2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105362322&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105362322 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016489 B6D jtl: Acta Oto-Laryngologica issn: 00016489 maglogo: Y pubinfo: dt: Jul2009 vid: 129 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 105362322 2010320379 10.1080/00016480802412789 NLM18819022 105362322 ppf: 786 ppct: 7 formats: fmt: @attributes: type: P tig: atl: MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy: preliminary evidence. aug: au: Marioni G Koussis H Gaio E Giacomelli L Bertolin A D'Alessandro E Scola A Ottaviano G de Filippis C Jirillo A Staffieri A Blandamura S affil: Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Via Giustiniani 2, 35100 Padova, Italy. E-mail: gino.marioni@unipd.it sug: subj: Carboplatin Therapeutic Use Carcinoma, Squamous Cell Therapy Head and Neck Neoplasms Therapy Protease Inhibitors Diagnostic Use Aged Carcinoma, Squamous Cell Risk Factors Chemotherapy, Cancer Data Analysis Software Drug Therapy, Combination Evaluation Research Female Fisher's Exact Test Head and Neck Neoplasms Radiotherapy Histological Techniques Kaplan-Meier Estimator Log-Rank Test Male Mann-Whitney U Test Middle Age Neoplasm Staging P-Value Neck Dissection Radiotherapy ROC Curve Sample Size Spearman's Rank Correlation Coefficient Survival Ultrasonography Human Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Conclusions: Our very preliminary results support the hypothesis that MASPIN expression in primary head and neck squamous cell carcinoma (HNSCC) may be a valuable parameter for predicting patients' responses to a treatment based on carboplatin plus vinorelbine combined with radiotherapy. Objectives: The roles of induction chemotherapy and combined chemoradiotherapy in the treatment of locally advanced unresectable HNSCCs have evolved rapidly. MASPIN has a unique tumour-suppressing activity. Experimental evidence has shown that MASPIN suppresses tumour growth, angiogenesis, invasion and metastasis. We investigated the potential prognostic roles of MASPIN and p53 in a series of HNSCCs treated with carboplatin plus vinorelbine combined with radiotherapy. Patients and methods: Nineteen consecutive stage III or IV HNSCC patients were recruited. The treatment plan consisted of the administration of carboplatin on day 1 and vinorelbine on days 1 and 8. Four weeks later, carboplatin was administered concomitantly with radiation therapy. Expression of MASPIN and p53 was determined immunohistochemically in HNSCC diagnostic biopsies. Results: A significant inverse relation was found between MASPIN expression and cN staging (p=0.003). From a prognostic viewpoint, MASPIN expression was directly correlated with chemoradiotherapy response (p=0.041). Moreover, the log-rank test showed a significant relationship between higher MASPIN expression and longer disease-free survival (p=0.03), overall survival (p=0.006) and disease-specific survival (p=0.007). pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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