A simulation-approximation approach to sample size planning for high-dimensional classification studies.
Classification studies with high-dimensional measurements and relatively small sample sizes are increasingly common. Prospective analysis of the role of sample sizes in the performance of such studies is important for study design and interpretation of results, but the complexity of typical pattern...
| Publicado en: | Biostatistics Vol. 10; no. 3; pp. 424 - 436 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
Jul2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105369575&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105369575 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14654644 N58 jtl: Biostatistics issn: 14654644 maglogo: N pubinfo: dt: Jul2009 vid: 10 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105369575 105369575 NLM19234308 2010328494 10.1093/biostatistics/kxp001 NLM19234308 105369575 ppf: 424 ppct: 12 formats: tig: atl: A simulation-approximation approach to sample size planning for high-dimensional classification studies. aug: au: de Valpine P Bitter HM Brown MP Heller J de Valpine, Perry Bitter, Hans-Marcus Brown, Michael P S Heller, Jonathan affil: Department of Environmental Science, Policy, & Management, University of California, 137 Hilgard Hall No. 3114, Berkeley, CA 94720-3114, USA sug: subj: Biometrics Methods Classification Methods Sample Size Algorithms Genomics Statistics and Numerical Data Linear Regression Multivariate Analysis Proteomics Statistics and Numerical Data Systems Analysis Human ab: Classification studies with high-dimensional measurements and relatively small sample sizes are increasingly common. Prospective analysis of the role of sample sizes in the performance of such studies is important for study design and interpretation of results, but the complexity of typical pattern discovery methods makes this problem challenging. The approach developed here combines Monte Carlo methods and new approximations for linear discriminant analysis, assuming multivariate normal distributions. Monte Carlo methods are used to sample the distribution of which features are selected for a classifier and the mean and variance of features given that they are selected. Given selected features, the linear discriminant problem involves different distributions of training data and generalization data, for which 2 approximations are compared: one based on Taylor series approximation of the generalization error and the other on approximating the discriminant scores as normally distributed. Combining the Monte Carlo and approximation approaches to different aspects of the problem allows efficient estimation of expected generalization error without full simulations of the entire sampling and analysis process. To evaluate the method and investigate realistic study design questions, full simulations are used to ask how validation error rate depends on the strength and number of informative features, the number of noninformative features, the sample size, and the number of features allowed into the pattern. Both approximation methods perform well for most cases but only the normal discriminant score approximation performs well for cases of very many weakly informative or uninformative dimensions. The simulated cases show that many realistic study designs will typically estimate substantially suboptimal patterns and may have low probability of statistically significant validation results. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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