A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala-hippocampal complex in chronic schizophrenia.
A progressive post-onset decrease in gray matter volume 1.5 years after first hospitalization in schizophrenia has been shown in superior temporal gyrus (STG). However, it is still controversial whether progressive volume reduction occurs in chronic schizophrenia in the STG and amygdala-hippocampal...
| Publicado en: | Schizophrenia Research Vol. 113; no. 1; pp. 84 - 95 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Aug2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105379271&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105379271 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09209964 3PT jtl: Schizophrenia Research issn: 09209964 maglogo: N pubinfo: dt: Aug2009 vid: 113 iid: 1 pid: 1004 pub: Elsevier B.V. artinfo: ui: 105379271 105379271 NLM19524408 2010340458 10.1016/j.schres.2009.05.004 NLM19524408 PMC2776716 105379271 ppf: 84 ppct: 11 formats: tig: atl: A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala-hippocampal complex in chronic schizophrenia. aug: au: Yoshida T McCarley RW Nakamura M Lee K Koo MS Bouix S Salisbury DF Morra L Shenton ME Niznikiewicz MA Yoshida, Takeshi McCarley, Robert W Nakamura, Motoaki Lee, KangUk Koo, Min-Seong Bouix, Sylvain Salisbury, Dean F Morra, Lindsay Shenton, Martha E Niznikiewicz, Margaret A affil: Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA 02301, USA sug: subj: Basal Ganglia Pathology Hippocampus Pathology Magnetic Resonance Imaging Methods Schizophrenia Temporal Lobe Pathology Adult Brain Mapping Chronic Disease Image Processing, Computer Assisted Male Middle Age Neural Pathways Pathology Neural Pathways Physiology Prospective Studies Psychological Tests Statistics Human Adult: 19-44 years Middle Aged: 45-64 years Male ab: A progressive post-onset decrease in gray matter volume 1.5 years after first hospitalization in schizophrenia has been shown in superior temporal gyrus (STG). However, it is still controversial whether progressive volume reduction occurs in chronic schizophrenia in the STG and amygdala-hippocampal complex (AHC), structures found to be abnormal in chronic schizophrenia. These structures were measured at two time points in 16 chronic schizophrenia patients and 20 normal comparison subjects using manual tracing with high spatial resolution magnetic resonance imaging (MRI). Average interscan interval was 3.1 years for schizophrenia patients and 1.4 years for healthy comparison subjects. Cross-sectional comparisons showed smaller relative volumes in schizophrenia compared with controls in posterior STG and AHC. An ANCOVA with interscan interval as a covariate showed there was no statistically significant progression of volume reduction in either the STG or AHC in the schizophrenia group compared with normal subjects. In the schizophrenia group, volume change in the left anterior AHC significantly correlated with PANSS negative symptoms. These data, and separately reported first episode data from our laboratory, suggest marked progression at the initial stage of schizophrenia, but less in chronic schizophrenia. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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