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A possible link between iron deficiency and gastrointestinal carcinogenesis.

There is definitive evidence that iron overload induces oxidative stress and DNA damage, which can enhance carcinogenic risk. However, other evidence suggests that iron deficiency and anemia also increase oxidative stress and DNA damage, which might increase carcinogenesis risk, especially in the ga...

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Published in:Nutrition & Cancer Vol. 61; no. 4; pp. 415 - 427
Main Authors: Prá D, Franke SIR, Henriques JAP, Fenech M
Format: review tables/charts Journal Article
Published: Taylor & Francis Ltd Jul/Aug2009
Online Access:View this record in EBSCOhost
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      dt: Jul/Aug2009
      vid: 61
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        atl: A possible link between iron deficiency and gastrointestinal carcinogenesis.
      aug:
        au:
          Prá D
          Franke SIR
          Henriques JAP
          Fenech M
        affil: Laboratório de Genetica, Universidade Católica de Pelotas (UCPEL), Rua Félix da Cunha, 412/204C, CEP 96010-000, Pelotas, RS, Brazil; daniel_pra@yahoo.com
      sug:
        subj:
          Gastrointestinal Neoplasms Diagnosis
          Iron Overload Complications
          Oncogenes Physiology
          Colonic Neoplasms Etiology
          Gastrointestinal Neoplasms Risk Factors
          Iron Blood
          Iron Deficiency
          Neoplasms
          Neoplasms Risk Factors
          Nutrition
          Stomach Neoplasms Etiology
      ab: There is definitive evidence that iron overload induces oxidative stress and DNA damage, which can enhance carcinogenic risk. However, other evidence suggests that iron deficiency and anemia also increase oxidative stress and DNA damage, which might increase carcinogenesis risk, especially in the gastrointestinal (GI) tract. The aim of this review is to provide essential background information for the accurate interpretation of future research on iron deficiency and increased GI cancer risk. Based on clinical, epidemiological, and experimental evidence, we discuss how iron deficiency might contribute to increased cancer risk through the impairment of several iron-dependent metabolic functions that are related to genome protection and maintenance (e.g., immune responses against cancer-initiated cells, metabolism of toxic compounds, and redox regulation of DNA biosynthesis and repair). Some epidemiological studies have indicated increased risk of GI tumors among individuals with low iron intake or low somatic iron stores, and in vivo data from rodent cancer models indicates the early progression of GI tumors during iron deficiency. Given the preliminary but consistent evidence relating iron deficiency to cancer risk and the fact that iron deficiency affects about one third of the world's population, further studies are needed to define the extent to which iron deficiency might increase GI cancer risk.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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