Activation of latent transforming growth factor-beta1 by nitric oxide in macrophages: role of soluble guanylate cyclase and MAP kinases.

The inducible nitric oxide (NO) synthase and the cytokine transforming growth factor-[beta]1 (TGF-[beta]1), both central modulators of wound healing, interact reciprocally: TGF-[beta]1 generally suppresses iNOS expression, while NO can induce and activate latent TGF-[beta]1. We have shown that chemi...

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Bibliographic Details

Published in:	Wound Repair & Regeneration Vol. 17; no. 4; pp. 578 - 589
Main Authors:	Metukuri MR, Namas R, Gladstone C, Clermont T, Jefferson B, Barclay D, Hermus L, Billiar TR, Zamora R, Vodovotz Y
Format:	equations & formulas pictorial research tables/charts Journal Article
Published:	Wiley-Blackwell Jul/Aug2009
Online Access:	View this record in EBSCOhost