Criteria for successful hepatitis B vaccination in adults: results of a case study.
BACKGROUND: Active immunization is the most important measure for controlling hepatitis B (HB) virus infection. The outcome of HB vaccination has been investigated in only a very small number of cohort studies, some of which found a number of cases of HBV infection. MATERIAL AND METHODS: Using a des...
| Publicado en: | Infection Vol. 37; no. 3; pp. 266 - 270 |
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| Autores principales: | , |
| Formato: | case study Journal Article |
| Publicado: |
Springer Nature
Jun2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105391672&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105391672 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Jun2009 vid: 37 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105391672 2010354413 10.1007/s15010-008-7410-y NLM18854934 105391672 ppf: 266 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Criteria for successful hepatitis B vaccination in adults: results of a case study. aug: au: Hofmann F Kralj N affil: Chair for Physiology Occupational Medicine and Prevention of Infectious diseases, University of Wuppertal, Gauss Str. 20, 42349, Wuppertal, Germany. sug: subj: Antibodies, Viral Blood Health Personnel Hepatitis B Vaccines Administration and Dosage Hepatitis B Prevention and Control Hepatitis Viruses Immunology Occupational Diseases Prevention and Control Female Hepatitis B Vaccines Immunology Hepatitis B Epidemiology Immunization Immunization Schedule Male Occupational Diseases Epidemiology Treatment Outcomes Female Male ab: BACKGROUND: Active immunization is the most important measure for controlling hepatitis B (HB) virus infection. The outcome of HB vaccination has been investigated in only a very small number of cohort studies, some of which found a number of cases of HBV infection. MATERIAL AND METHODS: Using a design different from that of earlier studies, we have investigated the occurrence of HBV infection and clinical HB disease in individuals who had a complete HB vaccination series. Reported cases of HB/HBV infections among 1235 German health care workers (HCW) were analyzed with special regard to the question of whether or not HB vaccination had taken place in the past. RESULTS: 23 persons had undergone a complete vaccination series with complete documentation: 18 were non-responders (post-vaccination anti-HBs < 10 IU/l), one was a low-responder (anti-HBs < 100 IU/l), and four were responders (100 IU/l).While all responders seroconverted without clinical sign of hepatitis, ten non-/low-responders contracted chronic HB/HBV infection and seven contracted self-limiting HB. CONCLUSION: Vaccination should be only regarded as 'successful', if the post-vaccination anti-HBs concentration is at least 100 IU/l. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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