Family history study of the familial coaggregation of borderline personality disorder with axis I and nonborderline dramatic cluster axis II disorders.

The purpose of this study was to assess the familial coaggregation of borderline personality disorder (BPD) with a full array of axis I disorders and four axis II disorders (antisocial personality disorder, histrionic personality disorder, narcissistic personality disorder, and sadistic personality...

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Publicado en:Journal of Personality Disorders Vol. 23; no. 4; pp. 357 - 370
Autores principales: Zanarini MC, Barison LK, Frankenburg FR, Reich DB, Hudson JI
Formato: research tables/charts Journal Article
Publicado: Guilford Publications Inc. Aug2009
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2009
      vid: 23
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      pub: Guilford Publications Inc.
      place: New York, New York
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        105406830
        2010371549
        10.1521/pedi.2009.23.4.357
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        105406830
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        atl: Family history study of the familial coaggregation of borderline personality disorder with axis I and nonborderline dramatic cluster axis II disorders.
      aug:
        au:
          Zanarini MC
          Barison LK
          Frankenburg FR
          Reich DB
          Hudson JI
        affil: Laboratory for the Study for Adult Development and the Psychiatric Epidemiology Research Program, McLean Hospital, and the Department of Psychiatry, Harvard Medical School, USA. zanarini@mclean.harvard.edu
      sug:
        subj:
          Borderline Personality Disorder Familial and Genetic
          Mental Disorders Familial and Genetic
          Adolescence
          Adult
          Borderline Personality Disorder Epidemiology
          Confidence Intervals
          Data Analysis Software
          Descriptive Statistics
          Female
          Fisher's Exact Test
          Funding Source
          Inpatients
          Interrater Reliability
          kappa Statistic
          Logistic Regression
          Male
          Massachusetts
          Mental Disorders Epidemiology
          Middle Age
          Odds Ratio
          Personality Disorders Epidemiology
          Personality Disorders Familial and Genetic
          Personality Tests
          Psychological Tests
          Questionnaires
          Semi-Structured Interview
          T-Tests
          Human
          Adolescent: 13-18 years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Female
          Male
      ab: The purpose of this study was to assess the familial coaggregation of borderline personality disorder (BPD) with a full array of axis I disorders and four axis II disorders (antisocial personality disorder, histrionic personality disorder, narcissistic personality disorder, and sadistic personality disorder) in the first-degree relatives of borderline probands and axis II comparison subjects. Four hundred and forty-five inpatients were interviewed about familial psychopathology using the Revised Family History Questionnaire-a semistructured interview of demonstrated reliability. Of these 445 subjects, 341 met both DIB-R and DSM-III-R criteria for BPD and 104 met DSM-III-R criteria for another type of personality disorder (and neither criteria set for BPD). The psychopathology of 1,580 first-degree relatives of borderline probands and 472 relatives of axis II comparison subjects was assessed. Using structural models for familial coaggregation, it was found that BPD coaggregates with major depression, dysthymic disorder, bipolar I disorder, alcohol abuse/dependence, drug abuse/dependence, panic disorder, social phobia, obsessive-compulsive disorder, generalized anxiety disorder, posttraumatic stress disorder, somatoform pain disorder, and all four axis II disorders studied. Taken together, the results of this study suggest that common familial factors, particularly in the areas of affective disturbance and impulsivity, contribute to borderline personality disorder.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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