The co-occurrence of autism and birth defects: prevalence and risk in a population-based cohort.
AIM :To estimate the prevalence of major birth defects among children with autism, the prevalence of autism in children with birth defects, and the risk for autism associated with having birth defects. METHOD: Retrospective cohort including all children born in Atlanta, GA, USA, 1986 to 1993, who su...
| Publicado en: | Developmental Medicine & Child Neurology Vol. 51; no. 10; pp. 779 - 787 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105430421&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105430421 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00121622 1VN jtl: Developmental Medicine & Child Neurology issn: 00121622 maglogo: Y pubinfo: dt: Oct2009 vid: 51 iid: 10 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105430421 2010401204 10.1111/j.1469-8749.2009.03310.x NLM19416313 105430421 ppf: 779 ppct: 8 formats: tig: atl: The co-occurrence of autism and birth defects: prevalence and risk in a population-based cohort. aug: au: Schendel DE Autry A Wines R Moore C affil: Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. dschendel@cdc.gov sug: subj: Abnormalities Epidemiology Autism Spectrum Disorder Epidemiology Child Child, Preschool Developmental Disabilities Epidemiology Disability Evaluation Female Georgia Health and Welfare Planning Male Prevalence Prospective Studies Retrospective Design Risk Factors Human Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: AIM :To estimate the prevalence of major birth defects among children with autism, the prevalence of autism in children with birth defects, and the risk for autism associated with having birth defects. METHOD: Retrospective cohort including all children born in Atlanta, GA, USA, 1986 to 1993, who survived to age 3 years and were identified through Georgia vital records. Children with autism and other developmental disabilities residing in Atlanta at ages 3 to 10 years in 1996 were identified through the Metropolitan Atlanta Developmental Disabilities Surveillance Program. Children with major birth defects through age 6 years were identified by the Metropolitan Atlanta Congenital Defects Program. RESULTS: Birth defects were found among 6% of children with autism (total n=617; 488 males, 129 females) and was associated with a near twofold increased risk for autism overall. However, the risk magnitude and statistical significance varied by type of birth defect. With any type of birth defect, the risk for autism accompanied by intellectual disability or other developmental disabilities was typically higher than the risk for autism alone. A 6:1 to 8:1 male bias was observed among children with autism and a birth defect. INTERPRETATION: Investigation of the association between autism and birth defects is warranted, especially for the role of birth defects in autism among sex-specific or autism subgroups. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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