Exposure as part of a systems approach for assessing risk.
BACKGROUND: The U.S. Environmental Protection Agency is facing large challenges in managing environmental chemicals with increasingly complex requirements for assessing risk that push the limits of our current approaches. To address some of these challenges, the National Research Council (NRC) devel...
| Publicado en: | Environmental Health Perspectives Vol. 117; no. 8; pp. 1181 - 1185 |
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| Autores principales: | , |
| Formato: | tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Aug2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105433972&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105433972 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Aug2009 vid: 117 iid: 8 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105433972 2010412163 10.1289/ehp.0800407 NLM19672394 105433972 ppf: 1181 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Exposure as part of a systems approach for assessing risk. aug: au: Sheldon LS Hubal EAC affil: National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. sheldon.linda@epa.gov sug: subj: Environmental Exposure Hazardous Materials Risk Assessment Toxicology Environmental Monitoring Genomics In Vitro Studies United States United States Environmental Protection Agency ab: BACKGROUND: The U.S. Environmental Protection Agency is facing large challenges in managing environmental chemicals with increasingly complex requirements for assessing risk that push the limits of our current approaches. To address some of these challenges, the National Research Council (NRC) developed a new vision for toxicity testing. Although the report focused only on toxicity testing, it recognized that exposure science will play a crucial role in a new risk-based framework. OBJECTIVE: In this commentary we expand on the important role of exposure science in a fully integrated system for risk assessment. We also elaborate on the exposure research needed to achieve this vision. DISCUSSION: Exposure science, when applied in an integrated systems approach for risk assessment, can be used to inform and prioritize toxicity testing, describe risks, and verify the outcomes of testing. Exposure research in several areas will be needed to achieve the NRC vision. For example, models are needed to screen chemicals based on exposure. Exposure, dose-response, and biological pathway models must be developed and linked. Advanced computational approaches are required for dose reconstruction. Monitoring methods are needed that easily measure exposure, internal dose, susceptibility, and biological outcome. Finally, population monitoring studies are needed to interpret toxicity test results in terms of real-world risk. CONCLUSION: This commentary is a call for the exposure community to step up to the challenge by developing a predictive science with the knowledge and tools for moving into the 21st century. pubtype: Academic Journal doctype: tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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