Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone.
BACKGROUND: Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by concomitant ozone exposure remains unknown. OBJECTIVE: In this study we assessed...
| Publicado en: | Environmental Health Perspectives Vol. 117; no. 8; pp. 1287 - 1293 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Aug2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105433988&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105433988 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Aug2009 vid: 117 iid: 8 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105433988 2010412179 10.1289/ehp.0900541 NLM19672410 105433988 ppf: 1287 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone. aug: au: Fakhri AA Ilic LM Wellenius GA Urch B Silverman F Gold DR Mittleman MA affil: Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. sug: subj: Heart Rate Variability Ozone Adverse Effects Particulate Matter Adverse Effects Adult Blood Pressure Canada Cardiovascular Risk Factors Crossover Design Data Analysis Software Dose-Response Relationship Electrocardiography Female Funding Source Male Middle Age Regression Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: BACKGROUND: Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by concomitant ozone exposure remains unknown. OBJECTIVE: In this study we assessed the impact of O(3) and particulate matter exposure on HRV in humans. METHODS: In a crossover design, 50 subjects (19-48 years of age) were randomized to 2-hr controlled exposures to filtered air (FA), concentrated ambient particles (CAPs), O(3), or combined CAPs and ozone (CAPs + O(3)). The primary end point was change in HRV between the start and end of exposure. Secondary analyses included blood pressure (BP) responses, and effect modification by asthmatic status. RESULTS: Achieved mean CAPs and O(3) exposure concentrations were 121.6 +/- 48.0 microg/m(3) and 113.9 +/- 6.6 ppb, respectively. In a categorical analysis, exposure had no consistent effect on HRV indices. However, the dose-response relationship between CAPs mass concentration and HRV indices seemed to vary depending on the presence of O(3). This heterogeneity was statistically significant for the low-frequency component of HRV (p = 0.02) and approached significance for the high-frequency component and time-domain measures of HRV. Exposure to CAPs + O(3) increased diastolic BP by 2.0 mmHg (SE, 1.2; p = 0.02). No other statistically significant changes in BP were observed. Asthmatic status did not modify these effects. CONCLUSION: The potentiation by O(3) of CAPs effects on diastolic BP and possibly HRV is of small magnitude in young adults. Further studies are needed to assess potential effects in more vulnerable populations. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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