Endoscopic diagnosis of Helicobacter pylori infection by rapid urease test in bleeding peptic ulcers: a prospective case-control study.
Goal: To assess the efficacy of rapid urease test (RUT) in patients with bleeding ulcers, as well as the effects of visible blood in the stomach and short-term (<24 h) use of standard-dose proton pump inhibitor (PPI) on RUT sensitivity.Background: The sensitivity of RUT in the diagnosis of Helicobac...
| Publicado en: | Journal of Clinical Gastroenterology Vol. 43; no. 2; pp. 133 - 140 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2009 Feb
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105455628&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105455628 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01920790 4BP jtl: Journal of Clinical Gastroenterology issn: 01920790 maglogo: N pubinfo: dt: 2009 Feb vid: 43 iid: 2 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105455628 105455628 NLM19230239 2010197102 10.1097/mcg.0b013e31816466ec NLM19230239 105455628 ppf: 133 ppct: 7 formats: tig: atl: Endoscopic diagnosis of Helicobacter pylori infection by rapid urease test in bleeding peptic ulcers: a prospective case-control study. aug: au: Tang JH Liu NJ Cheng HT Lee CS Chu YY Sung KF Lin CH Tsou YK Lien JM Cheng CL Tang, Jui-Hsiang Liu, Nai-Jen Cheng, Hao-Tsai Lee, Ching-Song Chu, Yin-Yi Sung, Kai-Feng Lin, Cheng-Hui Tsou, Yung-Kuan Lien, Jau-Min Cheng, Chi-Liang affil: Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taipei, Taiwan sug: subj: Endoscopy, Gastrointestinal Methods Helicobacter Infections Diagnosis Helicobacter Pylori Peptic Ulcer Complications Urease Analysis Adult Aged Case Control Studies Female Helicobacter Infections Microbiology Helicobacter Infections Pathology Male Middle Age Peptic Ulcer Diagnosis Peptic Ulcer Microbiology Peptic Ulcer Pathology Proton Pump Inhibitors Administration and Dosage Sensitivity and Specificity Time Factors Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Goal: To assess the efficacy of rapid urease test (RUT) in patients with bleeding ulcers, as well as the effects of visible blood in the stomach and short-term (<24 h) use of standard-dose proton pump inhibitor (PPI) on RUT sensitivity.Background: The sensitivity of RUT in the diagnosis of Helicobacter pylori in upper gastrointestinal bleeding has been reported with conflicting results.Study: This was a prospective case-control study evaluating 324 consecutive patients with bleeding peptic ulcers (study group) and 164 with uncomplicated ulcers (control group). The presence of H. pylori infection was determined by both RUT and histology. Prevalence of H. pylori infection and the RUT sensitivity in diagnosing the bacteria between study and control groups were conducted.Results: The prevalence of H. pylori infection in those with bleeding ulcers was significantly lower than that of controls (53.7% vs. 65.2%, P=0.015). The false-negative rate of RUT in the study group was significantly greater than that of the control group (16.7% vs. 5.6%, P=0.006), whereas the sensitivity rates in the study group with or without gastric blood were significantly lower than those of the controls (79.6% vs. 94.4%, P=0.005; 84.8% vs. 94.4%, P=0.019). There was no significant difference in RUT sensitivity between study group with or without visible gastric blood (P=0.41). The RUT sensitivity rate was also not significantly different between those treated with PPI and those without in patients with bleeding ulcers (82.7% vs. 85.7%, P=0.67).Conclusions: This study shows that the sensitivity of RUT in patients with bleeding ulcers is reduced. The presence of blood in the stomach and the short-term use of standard-dose PPI do not affect the RUT sensitivity in bleeding ulcers. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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