Air pollution and asthma severity in adults.
Background/objectives: There is evidence that exposure to air pollution affects asthma, but the effect of air pollution on asthma severity has not been addressed. The aim was to assess the relation between asthma severity during the past 12 months and home outdoor concentrations of air pollution.Met...
| Publicado en: | Occupational & Environmental Medicine Vol. 66; no. 3; pp. 182 - 189 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BMJ Publishing Group
Mar2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105460097&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105460097 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13510711 22H jtl: Occupational & Environmental Medicine issn: 13510711 maglogo: N pubinfo: dt: Mar2009 vid: 66 iid: 3 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 105460097 NLM19017701 2010202495 10.1136/oem.2007.038349 NLM19017701 105460097 ppf: 182 ppct: 7 formats: tig: atl: Air pollution and asthma severity in adults. aug: au: Rage E Siroux V Künzli N Pin I Kauffmann F Rage, E Siroux, V Künzli, N Pin, I Kauffmann, F affil: INSERM U780, 16 avenue Paul-Vaillant Couturier, Villejuif Cedex, France sug: subj: Air Pollution Adverse Effects Asthma Etiology Adult Air Pollutants Air Pollution Air Pollution, Indoor Adverse Effects Air Pollution, Indoor Asthma Physiopathology Environmental Monitoring Methods Female Lung Physiopathology Male Middle Age Nitrogen Oxides Odds Ratio Ozone Prospective Studies Relative Risk Residence Characteristics Seasons Severity of Illness Indices Sulfur Compounds Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background/objectives: There is evidence that exposure to air pollution affects asthma, but the effect of air pollution on asthma severity has not been addressed. The aim was to assess the relation between asthma severity during the past 12 months and home outdoor concentrations of air pollution.Methods: Asthma severity over the past 12 months was assessed in two complementary ways among 328 adult asthmatics from the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) examined between 1991 and 1995. The four-class severity score integrated clinical events and type of treatment. The five-level asthma score is based only on the occurrence of symptoms. Nitrogen dioxide (NO(2)), sulphur dioxide (SO(2)) and ozone (O(3)) concentrations were assigned to each residence using two different methods. The first was based on the closest monitor data from 1991 to 1995. The second consisted of spatial models that used geostatistical interpolations and then assigned air pollutants to the geo-coded residences (1998).Results: Higher asthma severity score was significantly related to the 8-hour average of ozone during April-September (O(3)-8 h) and the number of days (O(3)-days) with 8-hour ozone averages above 110 microg.m(-3) (for a 36-day increase, equivalent to the interquartile range, in O(3)-days, odds ratio 2.22 (95% confidence interval 1.61 to 3.07) for one class difference in score). Adjustment for age, sex, smoking habits, occupational exposure, and educational level did not alter results. Asthma severity was unrelated to NO(2). Both exposure assessment methods and severity scores resulted in very similar findings. SO(2) correlated with severity but reached statistical significance only for the model-based assignment of exposure.Conclusions: The observed associations between asthma severity and air pollution, in particular O(3), support the hypothesis that air pollution at levels far below current standards increases asthma severity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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