Potential dosimetric benefits of four-dimensional radiation treatment planning.
Purpose: To determine the extent of dosimetric differences between conventional three-dimensional (3D) dose calculations and four-dimensional (4D) dose calculations based on deformation of organ models. Methods and Materials: Four-dimensional dose calculations were retrospectively performed on compu...
| Publicado en: | International Journal of Radiation Oncology, Biology, Physics Vol. 73; no. 5; pp. 1560 - 1566 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Pergamon Press - An Imprint of Elsevier Science
Apr2009
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105485176&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105485176 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03603016 1ZQ jtl: International Journal of Radiation Oncology, Biology, Physics issn: 03603016 maglogo: N pubinfo: dt: Apr2009 vid: 73 iid: 5 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 105485176 NLM19231098 2010231653 10.1016/j.ijrobp.2008.12.024 NLM19231098 105485176 ppf: 1560 ppct: 6 formats: tig: atl: Potential dosimetric benefits of four-dimensional radiation treatment planning. aug: au: Starkschall G Britton K McAleer MF Jeter MD Kaus MR Bzdusek K Mohan R Cox JD Starkschall, George Britton, Keith McAleer, Mary F Jeter, Melenda D Kaus, Michael R Bzdusek, Karl Mohan, Radhe Cox, James D affil: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA sug: subj: Carcinoma, Non-Small-Cell Lung Radiotherapy Lung Neoplasms Radiotherapy Radiation Dosage Radiotherapy, Computer-Assisted Methods Algorithms Body Weights and Measures Carcinoma, Non-Small-Cell Lung Pathology Carcinoma, Non-Small-Cell Lung Radiography Diagnostic Imaging Methods Heart Radiography Lung Neoplasms Pathology Lung Neoplasms Radiography Movement Respiration Retrospective Design Spinal Cord Radiography Tomography, X-Ray Computed Methods Human ab: Purpose: To determine the extent of dosimetric differences between conventional three-dimensional (3D) dose calculations and four-dimensional (4D) dose calculations based on deformation of organ models. Methods and Materials: Four-dimensional dose calculations were retrospectively performed on computed tomography data sets for 15 patients with Stage III non-small-cell lung cancer, using a model-based deformable registration algorithm on a research version of a commercial radiation treatment planning system. Target volume coverage and doses to critical structures calculated using the 4D methodology were compared with those calculated using conventional 3D methodology. Results: For 11 of 15 patients, clinical target volume coverage was comparable in the 3D and 4D calculations, whereas for 7 of 15 patients, planning target volume coverage was comparable. For the other patients, the 4D calculation indicated a difference in target volume dose sufficiently great to warrant replanning. No correlations could be established between differences in 3D and 4D calculations and gross tumor volume size or extent of motion. Negligible differences were observed between 3D and 4D dose-volume relationships for normal anatomic structures. Conclusions: Use of 4D dose calculations, when possible, helps ensure that target volumes will not be underirradiated when respiratory motion may affect the dose distribution. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|