Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children.
Objective: To determine the effectiveness of Lactobacillus GG (LGG) in children with Helicobacter pylori infection undergoing eradication therapy.Materials and Methods: We conducted a double-blind, placebo-controlled, randomized trial comparing a 7-day, triple eradication regimen consisting of 2 ant...
| Publicado en: | Journal of Pediatric Gastroenterology & Nutrition Vol. 48; no. 4; pp. 431 - 437 |
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| Autores principales: | , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Wiley-Blackwell
2009 Apr
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105489656&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105489656 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02772116 N1F jtl: Journal of Pediatric Gastroenterology & Nutrition issn: 02772116 maglogo: N pubinfo: dt: 2009 Apr vid: 48 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105489656 105489656 NLM19330931 2010236717 NLM19330931 105489656 ppf: 431 ppct: 6 formats: tig: atl: Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children. aug: au: Szajewska H Albrecht P Topczewska-Cabanek A Szajewska, Hania Albrecht, Piotr Topczewska-Cabanek, Agnieszka affil: 2nd Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland sug: subj: Antibiotics Therapeutic Use Gastrointestinal Agents Therapeutic Use Helicobacter Infections Therapy Helicobacter Pylori Drug Effects Lactobacillus Omeprazole Therapeutic Use Probiotics Therapeutic Use Adolescence Amoxicillin Adverse Effects Amoxicillin Therapeutic Use Antibiotics Adverse Effects Child Clarithromycin Adverse Effects Clarithromycin Therapeutic Use Combined Modality Therapy Dietary Supplements Double-Blind Studies Drug Therapy, Combination Female Gastrointestinal Agents Adverse Effects Helicobacter Infections Drug Therapy Helicobacter Infections Microbiology Male Omeprazole Adverse Effects Placebos Therapeutic Use Human Adolescent: 13-18 years Child: 6-12 years Female Male ab: Objective: To determine the effectiveness of Lactobacillus GG (LGG) in children with Helicobacter pylori infection undergoing eradication therapy.Materials and Methods: We conducted a double-blind, placebo-controlled, randomized trial comparing a 7-day, triple eradication regimen consisting of 2 antibiotics (amoxicillin tablets, 25 mg/kg twice per day, and clarithromycin tablets, 10 mg/kg twice per day) plus a proton pump inhibitor (omeprazole capsules, 0.5 mg/kg twice per day) supplemented with LGG (109 colony-forming units) or placebo in 83 children with H pylori infection confirmed by 2 of 3 tests (13C-urea breath test, histopathology, rapid urease test). The primary outcome measure was the H pylori eradication rate. The secondary outcome measure was the proportion of patients who experienced therapy-related adverse effects during anti-H pylori treatment.Results: The groups did not differ with respect to H pylori eradication rates. Of the 34 children in the LGG group, 23 (69%) experienced eradication, compared with 22 of 32 children (68%) in the placebo group (RR 0.98, 95% CI 0.7-1.4). The groups did not differ with respect to adverse effects.Conclusions: In children with H pylori infection, supplementation of standard triple therapy with LGG did not significantly alter the eradication rate or side effects. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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