Postnatal betamethasone vs dexamethasone in premature infants with bronchopulmonary dysplasia: a pilot study.
OBJECTIVE: As effects of glucocorticoids differ with respect to preparation, dose and duration, we hypothesized that a postnatal regimen of a low-dose, short-course betamethasone treatment had comparable efficacy and a better safety profile compared to the conventional high-dose, dexamethasone. STUD...
| Published in: | Journal of Perinatology Vol. 29; no. 4; pp. 297 - 305 |
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| Main Authors: | , , , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Springer Nature
Apr2009
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105494865&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105494865 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07438346 DZF jtl: Journal of Perinatology issn: 07438346 maglogo: Y pubinfo: dt: Apr2009 vid: 29 iid: 4 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 105494865 2010242292 10.1038/jp.2008.194 NLM19052552 105494865 ppf: 297 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Postnatal betamethasone vs dexamethasone in premature infants with bronchopulmonary dysplasia: a pilot study. aug: au: DeCastro M El-Khoury N Parton L Ballabh P LaGamma EF affil: Division of Newborn Medicine, Department of Pediatrics, Regional Neonatal Center, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA. sug: subj: Betamethasone Therapeutic Use Bronchopulmonary Dysplasia Drug Therapy Dexamethasone Therapeutic Use Analysis of Variance Bronchopulmonary Dysplasia Physiopathology Descriptive Statistics Female Fisher's Exact Test Infant, Premature Intensive Care Units, Neonatal Male Mann-Whitney U Test Pilot Studies Record Review Respiration, Artificial T-Tests Human Female Male ab: OBJECTIVE: As effects of glucocorticoids differ with respect to preparation, dose and duration, we hypothesized that a postnatal regimen of a low-dose, short-course betamethasone treatment had comparable efficacy and a better safety profile compared to the conventional high-dose, dexamethasone. STUDY DESIGN: To test our hypothesis, we selected premature neonates with a birth weight <or=1000 g and a gestational age <or=29 weeks who were ventilated >10 postnatal days with an FiO(2)>0.4 and no ability to wean mechanical support for >or=3 consecutive days. These neonates either received twice daily dexamethasone 0.25 mg kg(-1) per dose intravenously for 3 days tapered to 0.125 mg kg(-1) per dose for 4 days (June 1999 to December 2000) or betamethasone 0.125 mg kg(-1) per day intramuscularly once per day for 3 days (January 2001 to December 2002). RESULT: We found a significant reduction in FiO(2) after 3 days in both glucocorticoid treatment groups. There were no significant differences between the two treatment groups in the clinical parameters including decrease in FiO(2), oxygenation index, mean airway pressure and percent extubation. Duration of ventilation, number of oxygen days and length of hospital stay were comparable in the two groups. Of particular interest, the betamethasone group showed fewer adverse effects, such as poor weight gain and high blood glucose, than the dexamethasone group. CONCLUSION: A short course of low-dose betamethasone has comparable efficacy and seemingly a better short-term safety profile compared to conventional dexamethasone treatment. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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