Predictors of atrial tachyarrhythmias in subjects with type 1 ECG pattern of Brugada syndrome.
BACKGROUND: Previous studies have demonstrated a high incidence of atrial tachyarrhythmias (ATs) in patients with Brugada syndrome (BS). The present study aimed to investigate whether various 12-lead electrocardiogram (ECG) and electrophysiological parameters may help to differentiate subjects with...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 32; no. 4; pp. 500 - 506 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105495028&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105495028 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Apr2009 vid: 32 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105495028 2010242460 10.1111/j.1540-8159.2009.02311.x NLM19335860 105495028 ppf: 500 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Predictors of atrial tachyarrhythmias in subjects with type 1 ECG pattern of Brugada syndrome. aug: au: Letsas KP Weber R Astheimer K Mihas CC Stockinger J Blum T Kalusche D Arentz T affil: Arrhythmia Service, Herz-Zentrum, Bad Krozingen, Germany. k.letsas@mail.gr sug: subj: Arrhythmia Diagnosis Brugada Syndrome Diagnosis Electrocardiography Methods Adult Descriptive Statistics Electrophysiology Female Fisher's Exact Test Kaplan-Meier Estimator Male Medical Records Middle Age Pearson's Correlation Coefficient ROC Curve T-Tests Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: BACKGROUND: Previous studies have demonstrated a high incidence of atrial tachyarrhythmias (ATs) in patients with Brugada syndrome (BS). The present study aimed to investigate whether various 12-lead electrocardiogram (ECG) and electrophysiological parameters may help to differentiate subjects with a high probability to develop ATs. METHODS AND RESULTS: The clinical records of 38 individuals (31 males, age 44.4 +/- 13.9) with spontaneous (n = 15) or ajmaline-induced (n = 23) type 1 ECG pattern of BS were analyzed. During a mean follow-up period of 4.6 +/- 2.2 years, nine subjects suffered ATs (24%). Six subjects displayed paroxysmal atrial fibrillation and three typical atrial flutter. Among the studied 12-lead ECG parameters, subjects with ATs exhibited increased values of P-wave duration in lead II, P-wave dispersion, PR interval in leads II, QRS duration in leads II and V(2), Tpeak-end interval in lead II, and Tpeak-end dispersion of the 12 leads in relation to those without ATs (P < 0.05). Among the assessed electrophysiological parameters, atrial-His (AH) and His-ventricular (HV) intervals were significantly prolonged in subjects with ATs (P < 0.05). Multiple Cox proportional hazards analysis revealed that P-wave duration in lead II, P-wave dispersion, Tpeak-end in lead II, Tpeak-end dispersion of the 12 leads, as well as AH and HV intervals are independent predictors of ATs in subjects with BS (P < 0.05). Cut-off point analysis showed that an HV interval>or=56 ms displayed the highest predictive ability (P < 0.01). CONCLUSION: Our findings demonstrate that simple 12-lead ECG and electrophysiological parameters may easily be applied to identify high-risk subjects with BS ECG phenotype to develop ATs. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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