Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study.
Atrophy is regarded a sensitive marker of neurodegenerative pathology. In addition to confirming the well-known presence of decreased global grey matter and hippocampal volumes in Alzheimer's disease, this study investigated whether deep grey matter structure also suffer degeneration in Alzheimer's...
| Published in: | Brain: A Journal of Neurology Vol. 131; no. 12; pp. 3277 - 3286 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Oxford University Press / USA
Dec2008
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105505149&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105505149 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00068950 2RY jtl: Brain: A Journal of Neurology issn: 00068950 maglogo: N pubinfo: dt: Dec2008 vid: 131 iid: 12 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105505149 105505149 NLM19022861 2010251394 10.1093/brain/awn278 NLM19022861 105505149 ppf: 3277 ppct: 9 formats: tig: atl: Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study. aug: au: de Jong LW van der Hiele K Veer IM Houwing JJ Westendorp RG Bollen EL de Bruin PW Middelkoop HA van Buchem MA van der Grond J de Jong, L W van der Hiele, K Veer, I M Houwing, J J Westendorp, R G J Bollen, E L E M de Bruin, P W Middelkoop, H A M van Buchem, M A van der Grond, J affil: Department of Radiology, University Medical Center, Leiden, The Netherlands sug: subj: Alzheimer's Disease Pathology Basal Ganglia Pathology Thalamus Pathology Aged Aged, 80 and Over Alzheimer's Disease Psychosocial Factors Atrophy Pathology Atrophy Psychosocial Factors Cognition Disorders Etiology Cognition Disorders Cross Sectional Studies Female Hippocampus Pathology Magnetic Resonance Imaging Methods Male Middle Age Neuropsychological Tests Human Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Atrophy is regarded a sensitive marker of neurodegenerative pathology. In addition to confirming the well-known presence of decreased global grey matter and hippocampal volumes in Alzheimer's disease, this study investigated whether deep grey matter structure also suffer degeneration in Alzheimer's disease, and whether such degeneration is associated with cognitive deterioration. In this cross-sectional correlation study, two groups were compared on volumes of seven subcortical regions: 70 memory complainers (MCs) and 69 subjects diagnosed with probable Alzheimer's disease. Using 3T 3D T1 MR images, volumes of nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen and thalamus were automatically calculated by the FMRIB's Integrated Registration and Segmentation Tool (FIRST)--algorithm FMRIB's Software Library (FSL). Subsequently, the volumes of the different regions were correlated with cognitive test results. In addition to finding the expected association between hippocampal atrophy and cognitive decline in Alzheimer's disease, volumes of putamen and thalamus were significantly reduced in patients diagnosed with probable Alzheimer's disease. We also found that the decrease in volume correlated linearly with impaired global cognitive performance. These findings strongly suggest that, beside neo-cortical atrophy, deep grey matter structures in Alzheimer's disease suffer atrophy as well and that degenerative processes in the putamen and thalamus, like the hippocampus, may contribute to cognitive decline in Alzheimer's disease. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|