Effect of hormonal variation on Raman spectra for cervical disease detection.
Objective: The objective of the study was to characterize the variations in normal cervical spectra because of menopausal status and location within the menstrual cycle. Using the information obtained, the accuracy of Raman spectroscopy to diagnose low-grade squamous intraepithelial lesion (LGSIL) w...
| Publicado en: | American Journal of Obstetrics & Gynecology Vol. 200; no. 5; pp. 512.e1 - 5121 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
May2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105508205&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105508205 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029378 AOG jtl: American Journal of Obstetrics & Gynecology issn: 00029378 maglogo: N pubinfo: dt: May2009 vid: 200 iid: 5 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 105508205 NLM19236872 2010256538 10.1016/j.ajog.2008.11.024 NLM19236872 PMC2692104 105508205 ppf: 512.e1 ppct: 1 formats: tig: atl: Effect of hormonal variation on Raman spectra for cervical disease detection. aug: au: Kanter EM Majumder S Kanter GJ Woeste EM Mahadevan-Jansen A Kanter, Elizabeth M Majumder, Shovan Kanter, Gary J Woeste, Emily M Mahadevan-Jansen, Anita affil: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA sug: subj: Cervix Dysplasia Diagnosis Hormones Metabolism Menopause Menstrual Cycle Spectrum Analysis Standards Adult Algorithms Cervical Smears Cervix Dysplasia Metabolism Colposcopy Diagnosis, Differential Female Middle Age Ovulation Reproducibility of Results Sensitivity and Specificity Spectrum Analysis Equipment and Supplies Human Adult: 19-44 years Middle Aged: 45-64 years Female ab: Objective: The objective of the study was to characterize the variations in normal cervical spectra because of menopausal status and location within the menstrual cycle. Using the information obtained, the accuracy of Raman spectroscopy to diagnose low-grade squamous intraepithelial lesion (LGSIL) will be improved.Study Design: A total of 133 patients undergoing either colposcopy or Papanicolaou smear were recruited from either Vanderbilt University or Tri-State Women's Health. Raman spectra were collected from both normal and diseased areas. The data were processed and analyzed using a multiclass discrimination and classification algorithm to determine whether the spectra were correctly classified.Results: Stratifying the data by menopausal state resulted in correctly classifying LGSIL 97% of the time (from 74%).Conclusion: This study brings Raman spectroscopy one step closer to clinical use by improving the sensitivity to differentiate LGSIL from normal. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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