Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy.
Minicolumnar changes that generalize throughout a significant portion of the cortex have macroscopic structural correlates that may be visualized with modern structural neuroimaging techniques. In magnetic resonance images (MRIs) of fourteen autistic patients and 28 controls, the present study found...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 39; no. 5; pp. 751 - 765 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105525564&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105525564 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: May2009 vid: 39 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105525564 2010276302 10.1007/s10803-008-0681-4 NLM19148739 105525564 ppf: 751 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy. aug: au: Casanova MF El-Baz A Mott M Mannheim G Hassan H Fahmi R Giedd J Rumsey JM Switala AE Farag A affil: Department of Psychiatry, University of Louisville, Louisville, KY 40292, USA. manuel.casanova@louisville.edu sug: subj: Autism Spectrum Disorder Physiopathology Cerebral Cortex Pathology Magnetic Resonance Imaging Telencephalon Pathology Adult Analysis of Variance Child Descriptive Statistics Intelligence Tests Interview Guides Male Matched Case Control Psychological Tests Scales Sensitivity and Specificity United States Wechsler Adult Intelligence Scale-Revised Human Adult: 19-44 years Child: 6-12 years Male ab: Minicolumnar changes that generalize throughout a significant portion of the cortex have macroscopic structural correlates that may be visualized with modern structural neuroimaging techniques. In magnetic resonance images (MRIs) of fourteen autistic patients and 28 controls, the present study found macroscopic morphological correlates to recent neuropathological findings suggesting a minicolumnopathy in autism. Autistic patients manifested a significant reduction in the aperture for afferent/efferent cortical connections, i.e., gyral window. Furthermore, the size of the gyral window directly correlated to the size of the corpus callosum. A reduced gyral window constrains the possible size of projection fibers and biases connectivity towards shorter corticocortical fibers at the expense of longer association/commisural fibers. The findings may help explain abnormalities in motor skill development, differences in postnatal brain growth, and the regression of acquired functions observed in some autistic patients. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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