Comparison of sonographically measured bowel wall vascularity, histology, and disease activity in Crohn's disease.
The purposes of this study was to provide a retrospective comparison of semiquantitatively measured bowel wall vascularity by power Doppler sonography, endoscopic-histopathological biopsy findings, and disease activity in patients with confirmed Crohn's disease. Thirty-two out of 1,332 patients with...
| Publicado en: | European Radiology Vol. 19; no. 6; pp. 1379 - 1387 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105531403&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105531403 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2009 vid: 19 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105531403 39563807 NLM19184036 2010280854 10.1007/s00330-008-1290-5 NLM19184036 105531403 ppf: 1379 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison of sonographically measured bowel wall vascularity, histology, and disease activity in Crohn's disease. aug: au: Drews BH Barth TF Hänle MM Akinli AS Mason RA Muche R Thiel R Pauls S Klaus J von Boyen G Kratzer W Drews, B H Barth, T F E Hänle, M M Akinli, A S Mason, R A Muche, R Thiel, R Pauls, S Klaus, J affil: Department of Internal Medicine I, Center for Internal Medicine, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany sug: subj: Crohn Disease Pathology Crohn Disease Ultrasonography Intestines Pathology Intestines Ultrasonography Neovascularization, Pathologic Pathology Neovascularization, Pathologic Ultrasonography Adolescence Adult Aged Clinical Assessment Tools Male Middle Age Reproducibility of Results Sensitivity and Specificity Human Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Male ab: The purposes of this study was to provide a retrospective comparison of semiquantitatively measured bowel wall vascularity by power Doppler sonography, endoscopic-histopathological biopsy findings, and disease activity in patients with confirmed Crohn's disease. Thirty-two out of 1,332 patients with histologically confirmed Crohn's disease (18 female, 14 male; mean age 38.8 years) met the inclusion criteria: ileocolonoscopy with biopsy and power Doppler sonographic determination of bowel wall vascularity with assessment of disease activity within a period of 5 days. Sonographic determination of bowel wall vascularity was based on a semiquantitative score. Endoscopic bowel wall biopsy specimens were assessed using a self-developed inflammation score and the disease activity was calculated using Crohn's disease activity index (CDAI). A significant association (p < 0.05) was shown for results of histology and bowel wall vascularity in the terminal ileum (kappa = 0.66; sensitivity 95%; specificity 69%). There was no observed association between CDAI and histology, although there was an association between CDAI and bowel wall vascularity (sensitivity 82%). Increased bowel wall vascularity in the terminal ileum measured by power Doppler ultrasound reflects inflammatory activity in histologically examined bowel wall. Power Doppler ultrasound may be able to monitor activity changes of the bowel wall determined by pharmaceutical treatment. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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