Dose recalculation and the Dose-Guided Radiation Therapy (DGRT) process using megavoltage cone-beam CT.
Purpose: At the University of California San Francisco, daily or weekly three-dimensional images of patients in treatment position are acquired for image-guided radiation therapy. These images can be used for calculating the actual dose delivered to the patient during treatment. In this article, we...
| Publicado en: | International Journal of Radiation Oncology, Biology, Physics Vol. 74; no. 2; pp. 583 - 593 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Pergamon Press - An Imprint of Elsevier Science
Jun2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105535461&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105535461 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03603016 1ZQ jtl: International Journal of Radiation Oncology, Biology, Physics issn: 03603016 maglogo: N pubinfo: dt: Jun2009 vid: 74 iid: 2 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 105535461 NLM19345518 2010277890 10.1016/j.ijrobp.2008.12.034 NLM19345518 105535461 ppf: 583 ppct: 10 formats: tig: atl: Dose recalculation and the Dose-Guided Radiation Therapy (DGRT) process using megavoltage cone-beam CT. aug: au: Cheung J Aubry JF Yom SS Gottschalk AR Celi JC Pouliot J Cheung, Joey Aubry, Jean-François Yom, Sue S Gottschalk, Alexander R Celi, Juan Carlos Pouliot, Jean affil: Department of Radiation Oncology, University of California San Francisco, Comprehensive Cancer Center, 94115, USA sug: subj: Diagnostic Imaging Methods Head and Neck Neoplasms Radiography Prostatic Neoplasms Radiography Radiotherapy, Computer-Assisted Methods Tomography, X-Ray Computed Methods Aged Bladder Radiography Brain Stem Radiography Calibration Computer Terminals Genitalia, Male Radiography Head and Neck Neoplasms Radiotherapy Larynx Radiography Male Middle Age Parotid Gland Radiography Prostatic Neoplasms Radiotherapy Radiation Dosage Radiation Injuries Prevention and Control Rectum Radiography Spinal Cord Radiography Temporomandibular Joint Radiography Aged: 65+ years Middle Aged: 45-64 years Male ab: Purpose: At the University of California San Francisco, daily or weekly three-dimensional images of patients in treatment position are acquired for image-guided radiation therapy. These images can be used for calculating the actual dose delivered to the patient during treatment. In this article, we present the process of performing dose recalculation on megavoltage cone-beam computed tomography images and discuss possible strategies for dose-guided radiation therapy (DGRT). Materials and Methods: A dedicated workstation has been developed to incorporate the necessary elements of DGRT. Patient image correction (cupping, missing data artifacts), calibration, completion, recontouring, and dose recalculation are all implemented in the workstation. Tools for dose comparison are also included. Examples of image correction and dose analysis using 6 head-and-neck and 2 prostate patient datasets are presented to show possible tracking of interfraction dosimetric endpoint variation over the course of treatment. Results: Analysis of the head-and-neck datasets shows that interfraction treatment doses vary compared with the planning dose for the organs at risk, with the mean parotid dose and spinal cord D(1) increasing by as much as 52% and 10%, respectively. Variation of the coverage to the target volumes was small, with an average D(5) dose difference of 1%. The prostate patient datasets revealed accurate dose coverage to the targeted prostate and varying interfraction dose distributions to the organs at risk. Conclusions: An effective workflow for the clinical implementation of DGRT has been established. With these techniques in place, future clinical developments in adaptive radiation therapy through daily or weekly dosimetric measurements of treatment day images are possible. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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