Cell therapy in patients with left ventricular dysfunction due to myocardial infarction.
Objectives: The purpose of this study was to determine the impact of autologous transplantation of mononuclear bone marrow cells on myocardial function in patients with left ventricular (LV) dysfunction due to an acute myocardial infarction. Methods: The randomized study included 82 patients with a...
| Publicado en: | Echocardiography Vol. 25; no. 8; pp. 888 - 898 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105551460&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105551460 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Sep2008 vid: 25 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105551460 2010022072 10.1111/j.1540-8175.2008.00696.x NLM18485010 105551460 ppf: 888 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Cell therapy in patients with left ventricular dysfunction due to myocardial infarction. aug: au: Panovsky R Meluzin J Janousek S Mayer J Kaminek M Groch L Prasek J Stanicek J Dusek L Hlinomaz O Kala P Klabusay M Koristek Z Navratil M affil: First Department of Internal Medicine/Cardioangiology, St. Anna Hospital, Masaryk University, Brno, Czech Republic sug: subj: Cell Therapy Evaluation Heart Ventricle, Left Pathology Myocardial Infarction Therapy Analysis of Variance Descriptive Statistics Female Funding Source Interrater Reliability Intrarater Reliability Male Middle Age P-Value Pearson's Correlation Coefficient Repeated Measures T-Tests Tomography, Emission-Computed Human Middle Aged: 45-64 years Female Male ab: Objectives: The purpose of this study was to determine the impact of autologous transplantation of mononuclear bone marrow cells on myocardial function in patients with left ventricular (LV) dysfunction due to an acute myocardial infarction. Methods: The randomized study included 82 patients with a first acute myocardial infarction treated with a stent implantation. This presentation is a subanalysis of 47 patients with left ventricular dysfunction-EF (ejection fraction) < or = 40%. Group H patients (n = 17) received higher number (100,000,000) of cells; Group L patients (n = 13) received lower number (10,000,000) of cells. The patients of control Group C (n = 17) were not treated with cells. The Doppler tissue imaging and single photon emission computed tomography were performed before cell transplantation and 3 months later. Results: At 3 months of follow-up, the baseline EF of 35%, 36%, 35% in Groups H, L, and C increased by 6% (P < 0.01 vs. baseline), 5% (P < 0.01 vs. baseline), and 4% (P = NS vs. baseline), respectively, as assessed by single photon emission computed tomography (P = NS between groups). The baseline number of akinetic segments of 6.9, 7.0, and 6.2 in H, L, and C groups decreased by 1.7 (P < 0.01 vs. baseline), 1.5 (P < 0.01 vs. baseline), and 0.7 (P = NS vs. baseline, P = NS between groups), respectively, as demonstrated by echocardiography. Conclusion: In our study, the statistically important effect of transplantation of mononuclear bone marrow cells on myocardial function was not found. Only an insignificant trend toward the improvement of global LV EF fraction was found at 3-month follow-up. (ECHOCARDIOGRAPHY, Volume 25, September 2008) pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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