Whole-tooth regeneration: it takes a village of scientists, clinicians, and patients.
A team of senior scientists was formed in 2006 to create a blueprint for the regeneration of whole human teeth along with all of the supporting structure of the dentition. The team included experts from diverse fields, each with a reputation for stellar accomplishment. Participants attacked the scie...
| Publicado en: | Journal of Dental Education Vol. 72; no. 8; pp. 903 - 912 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105552382&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105552382 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00220337 1H6 jtl: Journal of Dental Education issn: 00220337 maglogo: N pubinfo: dt: Aug2008 vid: 72 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105552382 NLM18676799 2010024701 NLM18676799 PMC2546443 105552382 ppf: 903 ppct: 9 formats: tig: atl: Whole-tooth regeneration: it takes a village of scientists, clinicians, and patients. aug: au: Snead ML Snead, Malcolm L affil: Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, CA, USA sug: subj: Regeneration Physiology Tissue Culture Techniques Methods Tooth Physiology Animals Bioinformatics Culture Media Fetal Development Physiology Fetal Development Genetic Techniques Models, Biological Periodontium Physiology Stem Cells Physiology Tissue Culture Techniques Tooth Transplantation ab: A team of senior scientists was formed in 2006 to create a blueprint for the regeneration of whole human teeth along with all of the supporting structure of the dentition. The team included experts from diverse fields, each with a reputation for stellar accomplishment. Participants attacked the scientific issues of tooth regeneration but, more importantly, each agreed to work collaboratively with experts from other disciplines to form a learning organization. A commitment to learn from one another produced a unique interdisciplinary and multidisciplinary team. Inspired by the Kennedy space program to send a man to the moon, with its myriad of problems and solutions that no one discipline could solve, this tooth regeneration team devised an ambitious plan that sought to use stem cell biology, engineering, and computational biology to replicate the developmental program for odontogenesis. In this manner, team members envisioned a solution that consisted of known or knowable fundamentals. They proposed a laboratory-grown tooth rudiment that would be capable of executing the complete program for odontogenesis when transplanted to a suitable host, recreating all of the dental tissues, periodontal ligament, cementum, and alveolar bone associated with the canonical tooth. This plan was designed to bring regenerative medicine fully into the dental surgery suite, although a lack of funding has so far prevented the plan from being carried out. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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