Presence of a micropapillary pattern in mucinous carcinomas of the breast and its impact on the clinical behavior.
Infiltrating micropapillary carcinomas (IMPC) of breast are highly angioinvasive tumors with poor prognosis. This study is based on the observation that a similar micropapillary pattern is also observed in mucinous carcinomas of breast. About 102 mucinous carcinomas were evaluated for the presence a...
| Publicado en: | Breast Journal Vol. 14; no. 5; pp. 412 - 421 |
|---|---|
| Autores principales: | , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep/Oct2008
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105554440&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105554440 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: Sep/Oct2008 vid: 14 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105554440 2010038149 10.1111/j.1524-4741.2008.00616.x NLM18673338 105554440 ppf: 412 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Presence of a micropapillary pattern in mucinous carcinomas of the breast and its impact on the clinical behavior. aug: au: Shet T Chinoy R affil: Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India; tanujashet@yahoo.com sug: subj: Breast Neoplasms Decision Making, Clinical Neoplasms, Cystic, Mucinous, and Serous Prognosis Survival Adult Aged Breast Neoplasms Classification Breast Neoplasms Diagnosis Breast Neoplasms Physiopathology Breast Neoplasms Prognosis Cox Proportional Hazards Model Data Analysis Software Data Analysis, Statistical Descriptive Statistics Female Kaplan-Meier Estimator Log-Rank Test Middle Age Record Review Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female ab: Infiltrating micropapillary carcinomas (IMPC) of breast are highly angioinvasive tumors with poor prognosis. This study is based on the observation that a similar micropapillary pattern is also observed in mucinous carcinomas of breast. About 102 mucinous carcinomas were evaluated for the presence and impact of this micropapillary pattern on the clinical behavior. Of these, 68 were mucinous carcinomas with a micropapillary pattern (MUMPC), 20 had MUMPC mixed with an infiltrating duct carcinoma component, two were solid variants of papillary carcinoma with mucin (SVPCMU), five had collision of the MUMPC and SVPCMU patterns and seven were mucinous carcinomas with signet ring cells (MUS). The factors negatively affecting overall survival (OAS) and disease-free survival (DFS) included the histological type of mucinous carcinoma, nodal metastases, an irregular tumor border, <50% mucin and an IMPC type of local recurrence or metastases. In the multivariate analysis, the histologic type of mucinous carcinoma and an irregular tumor border were most significant for OAS and DFS. Thus, 86% of mucinous carcinomas in this study were mucinous variants of the angioinvasive infiltrating micropapillary carcinomas. These tumors can produce IMPC type of metastases and thus should be treated aggressively. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|