Could the simplified (14)C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection?
Objective: The carbon-14 ((14)C) urea breath test (UBT) is a reliable and noninvasive technique for the diagnosis of Helicobacter pylori (HP) infection. The diagnostic performance of a new practical and low dose (14)C UBT system (Heliprobe, Stockholm, Sweden) was compared with those of other diagnos...
| Publicado en: | Annals of Nuclear Medicine Vol. 22; no. 7; pp. 611 - 617 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105556370&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105556370 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09147187 1CFC jtl: Annals of Nuclear Medicine issn: 09147187 maglogo: N pubinfo: dt: Aug2008 vid: 22 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105556370 105556370 NLM18756364 2010048449 10.1007/s12149-008-0168-6 NLM18756364 105556370 ppf: 611 ppct: 6 formats: tig: atl: Could the simplified (14)C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection? aug: au: Ozdemir E Karabacak NI Degertekin B Cirak M Dursun A Engin D Unal S Unlü M Ozdemir, Elif Karabacak, Neşe I Degertekin, Bülent Cirak, Meltem Dursun, Ayşe Engin, Doruk Unal, Selahattin Unlü, Mustafa affil: Department of Nuclear Medicine, Ankara Atatürk Training and Research Hospital, Ankara, Turkey sug: subj: Breath Tests Methods Helicobacter Infections Radiography Radioisotopes Diagnostic Use Urea Diagnostic Use Adult Benzopyrans Diagnostic Use Biopsy Female Fluorescent Dyes Diagnostic Use Histological Techniques Male Middle Age Polymerase Chain Reaction Sensitivity and Specificity Urea Analysis Urease Diagnostic Use Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: The carbon-14 ((14)C) urea breath test (UBT) is a reliable and noninvasive technique for the diagnosis of Helicobacter pylori (HP) infection. The diagnostic performance of a new practical and low dose (14)C UBT system (Heliprobe, Stockholm, Sweden) was compared with those of other diagnostic tests, namely, rapid urease test (RUT), histopathology, and DNA detection using polymerase chain reaction (PCR). Methods: Eighty-nine patients (mean age = 45 +/- 13, 30 men) with dyspeptic complaints who underwent an endoscopic procedure were studied. Biopsy specimens acquired during the procedure were subjected to RUT, histopathological examination using hematoxylin and eosin (HP-HE) and PCR. All patients underwent UBT using the Heliprobe system on a different day. The gold standard for HP positivity was defined as any two of the three tests being positive, excluding UBT, and the sensitivity and specificity of any single test alone were determined using this gold standard. Whenever only one test was positive, it was considered to be a false-positive one. Results: With the gold standard used in this study, 59 (66%) patients were diagnosed HP positive. The Heliprobe method detected HP infection with 96.6% sensitivity and 100% specificity and had the best diagnostic performance when compared with all the other methods. The sensitivity and specificity of the other methods for the detection of HP positivity were 89.8% and 100% for RUT, 93.2% and 63.3% for PCR, and 93.2% and 76.6% for HP-HE, respectively. Areas under the receiver-operating characteristic were 0.977 for UBT, 0.947 for RUT, 0.84 for HP-HE, and 0.775 for PCR. Conclusions: Using a combination of invasive diagnostic tests as the gold standard, Heliprobe UBT was found to be highly sensitive and specific for the diagnosis of HP infection in patients with dyspeptic complaints. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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