The Leishmania HSP20 is antigenic during natural infections, but, as DNA vaccine, it does not protect BALB/c mice against experimental L. amazonensis infection.
Protozoa of the genus Leishmania are causative agents of leishmaniasis, an important health problem in both human and veterinary medicine. Here, we describe a new heat shock protein (HSP) in Leishmania, belonging to the small HSP (sHSP) family in kinetoplastids. The protein is highly conserved in di...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 9p - 10 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2008 Regular issue
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105557253&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105557253 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2008 Regular issue pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105557253 2010050610 10.1155/2008/695432 NLM18401455 105557253 ppf: 9p ppct: 1 formats: fmt: @attributes: type: P tig: atl: The Leishmania HSP20 is antigenic during natural infections, but, as DNA vaccine, it does not protect BALB/c mice against experimental L. amazonensis infection. aug: au: Montalvo-Álvarez AM Folgueira C Carrión J Monzote-Fidalgo L Cañavate C Requena JM affil: Instituto de Medicina Tropical 'Pedro Kouri', La Habana, Cuba. sug: subj: Leishmania Immunology Leishmaniasis Immunology Leishmaniasis Prevention and Control Proteins Administration and Dosage Proteins Immunology Vaccines Administration and Dosage Animal Studies Antigens Immunology Funding Source Mice Models, Biological Treatment Outcomes Vaccines Immunology ab: Protozoa of the genus Leishmania are causative agents of leishmaniasis, an important health problem in both human and veterinary medicine. Here, we describe a new heat shock protein (HSP) in Leishmania, belonging to the small HSP (sHSP) family in kinetoplastids. The protein is highly conserved in different Leishmania species, showing instead significant divergence with sHSP's from other organisms. The humoral response elicited against this protein during Leishmania infection has been investigated in natural infected humans and dogs, and in experimentally infected hamsters. Leishmania HSP20 is a prominent antigen for canine hosts; on the contrary, the protein seems to be a poor antigen for human immune system. Time-course analysis of appearance of anti-HSP20 antibodies in golden hamsters indicated that these antibodies are produced at late stages of the infection, when clinical symptoms of disease are patent. Finally, the protective efficacy of HSP20 was assessed in mice using a DNA vaccine approach prior to challenge with Leishmania amazonensis. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|