Effect of the ethinylestradiol/norelgestromin contraceptive patch on body composition. Results of bioelectrical impedance analysis in a population of Italian women.
Background: As weight gain is one of the most frequently cited reasons for not using and for discontinuing hormonal contraceptives, in an open-label, single-arm, multicentre clinical study we evaluated the effect of the ethinylestradiol/norelgestromin contraceptive patch (EVRA, Janssen-Cilag Interna...
| Publicado en: | Nutrition Journal Vol. 7; pp. 21 - 22 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105564558&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105564558 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14752891 1CYY jtl: Nutrition Journal issn: 14752891 maglogo: N pubinfo: dt: 2008 vid: 7 pid: 24147 pub: BioMed Central artinfo: ui: 105564558 105564558 NLM18727825 2010079575 10.1186/1475-2891-7-21 NLM18727825 105564558 ppf: 21 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Effect of the ethinylestradiol/norelgestromin contraceptive patch on body composition. Results of bioelectrical impedance analysis in a population of Italian women. aug: au: Piccoli A Crosignani P Nappi C Ronsini S Bruni V Marelli S Piccoli, Antonio Crosignani, PierGiorgio Nappi, Carmine Ronsini, Salvatore Bruni, Vincenzina Marelli, Silvia affil: Department of Medical and Surgical Sciences, University of Padova, Italy sug: subj: Body Composition Drug Effects Contraceptives, Oral Combined Administration and Dosage Contraceptives, Oral Combined Adverse Effects Weight Gain Drug Effects Administration, Transcutaneous Adolescence Adult Amines Administration and Dosage Amines Adverse Effects Body Mass Index Body Water Drug Effects Body Water Metabolism Clinical Trials Electric Impedance Female Middle Age Progestational Hormones, Synthetic Administration and Dosage Progestational Hormones, Synthetic Adverse Effects Progestational Hormones, Synthetic Analogs and Derivatives Steroids Administration and Dosage Steroids Adverse Effects Weight Gain Physiology Human Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female ab: Background: As weight gain is one of the most frequently cited reasons for not using and for discontinuing hormonal contraceptives, in an open-label, single-arm, multicentre clinical study we evaluated the effect of the ethinylestradiol/norelgestromin contraceptive patch (EVRA, Janssen-Cilag International, Belgium) on body composition using bioelectrical impedance analysis (BIA).Methods: Body weight and impedance vector components (resistance (R) and reactance (Xc), at 50 kHz frequency, Akern-RJL Systems analyzer) were recorded before entry, after 1, 3 and 6 months in 182 Italian healthy women aged 29 yr (18 to 45), and with BMI 21.8 kg/m2 (16 to 31). Total body water (TBW) was estimated with a BIA regression equation. Vector BIA was performed with the RXc mean graph method and the Hotelling's T2 test for paired and unpaired data.Results: After 6 months body weight increased by 0.64 kg (1.1%) and TBW increased by 0.51 L (1.7%). The pattern of impedance vector displacement indicated a small increase in soft tissue hydration (interstitial gel fluid). Body composition changes did not significantly differ among groups of previous contraceptive methods. Arterial blood pressure did not significantly change over time.Conclusion: After 6 months of treatment with the ethinylestradiol/norelgestromin contraceptive patch we found a minimal, clinically not relevant, increase in body weight less than 1 kg that could be attributed to an adaptive interstitial gel hydration. This fluctuation is physiological as confirmed by the lack of any effect on blood pressure. This could be useful in increasing women's choice, acceptability and compliance of the ethinylestradiol/norelgestromin contraceptive patch. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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