Efficacy of intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine in preventing anaemia in pregnancy among Nigerian women.
Objective: To evaluate the efficacy of intermittent preventive treatment of malaria using sulphadoxine-pyrimethamine (SP) in the prevention of anaemia in women of low parity in a low socio-economic, malaria endemic setting. Method: The study design was an open randomized control trial comparing anae...
| Publicado en: | Maternal & Child Health Journal Vol. 12; no. 6; pp. 692 - 699 |
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| Autores principales: | , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105565815&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105565815 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10927875 N9J jtl: Maternal & Child Health Journal issn: 10927875 maglogo: N pubinfo: dt: Nov2008 vid: 12 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105565815 105565815 2010084432 10.1007/s10995-008-0319-3 NLM18274885 105565815 ppf: 692 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Efficacy of intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine in preventing anaemia in pregnancy among Nigerian women. aug: au: Asa OO Onayade AA Fatusi AO Ijadunola KT Abiona TC affil: Department of Community Health, Obafemi Awolowo, Univeristy Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria; adesegunfatusi@yahoo.co.uk sug: subj: Anemia Prevention and Control Antimalarials Therapeutic Use Malaria Drug Therapy Malaria In Pregnancy Malaria Prevention and Control Adolescence Adult Anemia Diagnosis Antimalarials Administration and Dosage Bivariate Statistics Chi Square Test Chloroquine Clinical Trials Confidence Intervals Data Analysis Software Demography Descriptive Statistics Female Gestational Age Hematocrit Logistic Regression Mantel-Haenszel Test Multivariate Analysis Nigeria Nonprobability Sample Odds Ratio Parity Poverty Power Analysis Pregnancy Pyrimethamine Random Assignment Relative Risk Time Factors Treatment Outcomes Human Adolescent: 13-18 years Adult: 19-44 years Female ab: Objective: To evaluate the efficacy of intermittent preventive treatment of malaria using sulphadoxine-pyrimethamine (SP) in the prevention of anaemia in women of low parity in a low socio-economic, malaria endemic setting. Method: The study design was an open randomized control trial comparing anaemia incidence among pregnant women on intermittent presumptive treatment of malaria with SP with those on chloroquine (CQ). A total of 352 primigravid and secondigravid women between 16 and 30 weeks gestation receiving antenatal care at the Primary Health Care Center, Enuwa in Ile-Ife, Osun State, Nigeria were serially recruited and randomly allocated into experimental and control groups of 176 each. The experimental group received SP (to a maximum of three doses depending on the gestational age at enrollment into the study) while the control group had treatment doses of CQ at recruitment and subsequently only if they had symptoms suggestive of malaria. The primary outcome measure was anaemia (haematocrit < 30) at 34 weeks of gestation. Result: At recruitment and 34 weeks gestation, there was no statistically significant difference between the experimental and control group in terms of socio-demographic characteristics and past medical history. Thirty-three (22.6%) and 52 (37.1%) women in the study and control groups, respectively, had anaemia (protective efficacy 49.5%, p = 0.01). With multivariate analysis, controlling for the possible confounding effects of education, parity, haemoglobin level at booking and malaria parasitaemia in peripheral blood, the difference in the incidence of anaemia in the two groups remained significant ( p = 0.01; odds ratio = 0.5; 95% confidence interval = 0.29-0.85). Conclusion: The IPT regime with sulphadoxine-pyrimethamine is an effective, practicable strategy to decrease risk of anaemia in women of low parity residing in areas endemic for malaria. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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