Computerized analysis of digital subtraction angiography: a tool for quantitative in-vivo vascular imaging.

The purpose of our study was to develop a user-independent computerized tool for the automated segmentation and quantitative assessment of in vivo-acquired digital subtraction angiography (DSA) images. Vessel enhancement was accomplished based on the concept of image structural tensor. The developed...

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Publicado en:Journal of Digital Imaging Vol. 21; no. 4; pp. 433 - 446
Autores principales: Kagadis G, Spyridonos P, Karnabatidis D, Diamantopoulos A, Athanasiadis E, Daskalakis A, Katsanos K, Cavouras D, Mihailidis D, Siablis D, Nikiforidis G
Formato: diagnostic images equations & formulas pictorial research tables/charts Journal Article
Publicado: Springer Nature Dec2008
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2008
      vid: 21
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      pub: Springer Nature
      place: New York, New York
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        2010092422
        10.1007/s10278-007-9047-2
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        atl: Computerized analysis of digital subtraction angiography: a tool for quantitative in-vivo vascular imaging.
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        au:
          Kagadis G
          Spyridonos P
          Karnabatidis D
          Diamantopoulos A
          Athanasiadis E
          Daskalakis A
          Katsanos K
          Cavouras D
          Mihailidis D
          Siablis D
          Nikiforidis G
        affil: Department of Medical Physics, School of Medicine, University of Patras, 265 00 Rion, Greece
      sug:
        subj:
          Angiography, Digital Subtraction
          Blood Vessels Radiography
          Radiographic Image Interpretation, Computer-Assisted
          Radiographic Magnification
          Algorithms
          Evaluation Research
          False Negative Results
          False Positive Results
          Funding Source
          Neovascularization, Physiologic
          ROC Curve
          Software
          Human
      ab: The purpose of our study was to develop a user-independent computerized tool for the automated segmentation and quantitative assessment of in vivo-acquired digital subtraction angiography (DSA) images. Vessel enhancement was accomplished based on the concept of image structural tensor. The developed software was tested on a series of DSA images acquired from one animal and two human angiogenesis models. Its performance was evaluated against manually segmented images. A receiver's operating characteristic curve was obtained for every image with regard to the different percentages of the image histogram. The area under the mean curve was 0.89 for the experimental angiogenesis model and 0.76 and 0.86 for the two clinical angiogenesis models. The coordinates of the operating point were 8.3% false positive rate and 92.8% true positive rate for the experimental model. Correspondingly for clinical angiogenesis models, the coordinates were 8.6% false positive rate and 89.2% true positive rate and 9.8% false positive rate and 93.8% true positive rate, respectively. A new user-friendly tool for the analysis of vascular networks in DSA images was developed that can be easily used in either experimental or clinical studies. Its main characteristics are robustness and fast and automatic execution.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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