Involvement patterns in myotilinopathy and desminopathy detected by a novel neuromuscular whole-body MRI protocol.
Whole-body MRI (WB-MRI) has been successfully applied for oncologic and cardiovascular diagnostics, whereas imaging in myopathies usually employs dedicated protocols restricted to areas of specific interest. In this study, we propose a comprehensive neuromuscular WB-MRI protocol. Eighteen patients w...
| Published in: | European Radiology Vol. 18; no. 12; pp. 2922 - 2937 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Dec2008
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105570961&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105570961 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2008 vid: 18 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105570961 35166625 NLM18648820 2010095291 10.1007/s00330-008-1071-1 NLM18648820 105570961 ppf: 2922 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Involvement patterns in myotilinopathy and desminopathy detected by a novel neuromuscular whole-body MRI protocol. aug: au: Schramm N Born C Weckbach S Reilich P Walter MC Reiser MF Schramm, Nicolai Born, Christine Weckbach, Sabine Reilich, Peter Walter, Maggie C Reiser, Maximilian F affil: Institute for Clinical Radiology, Ludwig-Maximilians-University, Ziemssenstr. 1, 80336, Munich, Germany sug: subj: Algorithms Diagnostic Imaging Methods Image Enhancement Methods Image Interpretation, Computer Assisted Methods Magnetic Resonance Imaging Methods Muscular Dystrophy Diagnosis Neuromuscular Diseases Diagnosis Adult Aged Aged, 80 and Over Female Male Middle Age Reproducibility of Results Sensitivity and Specificity Human Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Whole-body MRI (WB-MRI) has been successfully applied for oncologic and cardiovascular diagnostics, whereas imaging in myopathies usually employs dedicated protocols restricted to areas of specific interest. In this study, we propose a comprehensive neuromuscular WB-MRI protocol. Eighteen patients with degenerative and inflammatory muscle diseases were included. Whole-body imaging was performed on a 1.5-T MR system using parallel imaging. Examination time was 41:26 min. Coronal and axial T1-weighted and coronal short tau inversion recovery (STIR) sequences of the whole body were acquired. Images were analysed by two radiologists. With this protocol we could detect characteristic involvement patterns in different myofibrillar myopathies (MFMs): Patients with myotilinopathy showed frequent involvement of the rhomboid muscles (4/5), the erector spinae (5/5), the biceps femoris and the semimembranosus (5/5), while the semitendinosus was relatively spared (2/5). In contrast, in desminopathy patients the ilipsoas (3/4), the sartorius, (3/4), the gracilis (3/4) and the semitendinosus (3/4) were frequently involved, while the semimembranosus was spared (1/4). As shown for MFMs, WB-MRI is an appropriate modality to detect fatty infiltration and oedema in skeletal muscles. WB-MRI could be more useful than dedicated examinations for differential diagnosis, muscle biopsy planning and noninvasive follow-up examinations. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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