Effect of Greek raisins (Vitis vinifera L.) from different origins on gastric cancer cell growth.
Currants and Sultanas (Vitis vinifera L.) are dried vine products produced in Greece and used broadly in the Mediterranean diet. We aimed to investigate the gastric cancer preventive activity of methanol extracts obtained from currants from three different origins in Greece (Vostizza, Nemea, and Mes...
| Publicado en: | Nutrition & Cancer Vol. 60; no. 6; pp. 792 - 800 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2008
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105579303&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105579303 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2008 vid: 60 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 105579303 105579303 2010108767 10.1080/01635580802295776 NLM19005979 105579303 ppf: 792 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Effect of Greek raisins (Vitis vinifera L.) from different origins on gastric cancer cell growth. aug: au: Kaliora AC Kountouri AM Karathanos VT Koumbi L Papadopoulos NG Andrikopoulos NK affil: Department of Science of Dietetics & Nutrition, Harokopion University of Athens, Athens, Greece. sug: subj: Mediterranean Diet Evaluation Stomach Neoplasms Etiology Apoptosis Descriptive Statistics Fluorescence Polarization Methods Funding Source Neoplasms Classification Neoplasms Diagnosis Nutrition RNA T-Tests Tissue Culture Techniques Methods Human ab: Currants and Sultanas (Vitis vinifera L.) are dried vine products produced in Greece and used broadly in the Mediterranean diet. We aimed to investigate the gastric cancer preventive activity of methanol extracts obtained from currants from three different origins in Greece (Vostizza, Nemea, and Messinia) as well as methanol extracts obtained from Sultanas cultivated in the island of Crete as to inhibition of cell proliferation, induction of apoptosis, and inhibition of inflammation. All extracts from 500 microg dried raisins studied suppressed cell proliferation, significantly those obtained from Sultanas from Crete and currants from Nemea. Flow cytometric analysis of Annexin-V labeled cells indicated that Cretan Sultana, Nemea, and Messinia currants at 500 microg dried product/ml medium significantly induced cell death. All extracts from 500 microg dried raisins statistically decreased protein and mRNA levels of ICAM-1 in TNF-alpha stimulated cells. Measurement of IL-8 protein levels and quantification for IL-8 mRNA showed no significant decrease. These results indicate that the methanol extracts from currants, rich in phenolic compounds, exhibit cancer preventive efficacy by limiting cell proliferation, inducing cell death, and suppressing ICAM-1 levels in AGS cells. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|