Magnetic nanoparticle imaging by means of minimum norm estimates from remanence measurements.
In magnetic nanoparticle imaging, magnetic nanoparticles are coated and functionalized to bind to specific targets. After measuring their magnetic relaxation or remanence, their distribution can be determined by means of inverse methods. The reconstruction algorithm presented in this paper includes...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 46; no. 12; pp. 1177 - 1186 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105579903&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105579903 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Dec2008 vid: 46 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105579903 NLM18841404 2010109423 10.1007/s11517-008-0404-1 NLM18841404 105579903 ppf: 1177 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Magnetic nanoparticle imaging by means of minimum norm estimates from remanence measurements. aug: au: Baumgarten D Liehr M Wiekhorst F Steinhoff U Münster P Miethe P Trahms L Haueisen J Baumgarten, Daniel Liehr, Mario Wiekhorst, Frank Steinhoff, Uwe Münster, Peter Miethe, Peter Trahms, Lutz Haueisen, Jens affil: Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, P.O. Box 100565, 98684 Ilmenau, Germany sug: subj: Electrodiagnosis Methods Magnetics Methods Nanotechnology Algorithms Computer Simulation Image Processing, Computer Assisted Methods Phantoms, Imaging ab: In magnetic nanoparticle imaging, magnetic nanoparticles are coated and functionalized to bind to specific targets. After measuring their magnetic relaxation or remanence, their distribution can be determined by means of inverse methods. The reconstruction algorithm presented in this paper includes first a dipole fit using a Levenberg-Marquardt optimizer to determine the reconstruction plane. Secondly, a minimum norm estimate is obtained on a regular grid placed in that plane. Computer simulations involving different parameter sets and conditions show that the used approach allows for the reconstruction of distributed sources, although the reconstructed shapes are distorted by blurring effects. The reconstruction quality depends on the signal-to-noise ratio of the measurements and decreases with larger sensor-source distances and higher grid spacings. In phantom measurements, the magnetic remanence of nanoparticle columns with clinical relevant sizes is determined with two common measurement systems. The reconstructions from these measurements indicate that the approach is applicable for clinical measurements. Our results provide parameter sets for successful application of minimum norm approaches to Magnetic Nanoparticle Imaging. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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