Neural substrates of cognitive skill learning in Parkinson's disease.
While cognitive skill learning is normally acquired implicitly through frontostriatal circuitry in healthy individuals, neuroimaging studies suggest that patients with Parkinson's disease (PD) do so by activating alternate, intact brain areas associated with explicit memory processing. To further te...
| Publicado en: | Brain & Cognition Vol. 68; no. 2; pp. 134 - 144 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Academic Press Inc.
Nov2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105583248&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105583248 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02782626 88Z jtl: Brain & Cognition issn: 02782626 maglogo: N pubinfo: dt: Nov2008 vid: 68 iid: 2 pid: 735 pub: Academic Press Inc. place: Burlington, Massachusetts artinfo: ui: 105583248 105583248 NLM18456379 2010113355 10.1016/j.bandc.2008.03.008 NLM18456379 105583248 ppf: 134 ppct: 10 formats: tig: atl: Neural substrates of cognitive skill learning in Parkinson's disease. aug: au: Beauchamp MH Dagher A Panisset M Doyon J Beauchamp, M H Dagher, A Panisset, M Doyon, J affil: Département de Psychologie, Université de Montréal, C.P. 6128 Succursale Centre-Ville, Montreal, Que., Canada sug: subj: Cognition Cognition Disorders Learning Parkinson Disease Aged Female Frontal Lobe Physiology Hippocampus Male Memory Middle Age Neuropsychological Tests Neuroradiography Problem Solving Tomography, Emission-Computed Human Aged: 65+ years Middle Aged: 45-64 years Female Male ab: While cognitive skill learning is normally acquired implicitly through frontostriatal circuitry in healthy individuals, neuroimaging studies suggest that patients with Parkinson's disease (PD) do so by activating alternate, intact brain areas associated with explicit memory processing. To further test this hypothesis, 10 patients with PD and 12 healthy controls were tested on a modified, learning version of the Tower of London task while undergoing positron emission tomography at four different time points over the course of learning. Despite having less accurate problem solving abilities than controls, PD patients were able to acquire the skill learning task. However, as compared to controls, they maintained higher levels of cerebral blood flow activity in the dorsolateral prefrontal cortex and hippocampus and showed an increase in activity in the frontopolar cortex and posterior cingulate over the course of learning. These findings reflect a shift to the explicit memory system in PD patients, enabling them to learn this cognitive skill, which is normally acquired by control subjects using implicit learning strategies and frontostriatal circuitry. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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