Urinary annexin V in children with nephrotic syndrome: a new prognostic marker?
Annexin V has a molecular weight of 32–35 kDa and has been reported to possess anticoagulant activity, inhibition of phospholipase A2, regulation of membrane transport, proliferation and signal transduction. It is reported that urinary annexin V concentration may be an indicator of apoptosis and acu...
| Published in: | Pediatric Nephrology Vol. 23; no. 1; pp. 79 - 83 |
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| Main Authors: | , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Jan2008
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105588271&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105588271 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Jan2008 vid: 23 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105588271 2010123001 10.1007/s00467-007-0606-z NLM17999093 105588271 ppf: 79 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Urinary annexin V in children with nephrotic syndrome: a new prognostic marker? aug: au: Simsek B Buyukcelik M Soran M Bayazit AK Noyan A Seydaoglu G Anarat A affil: Department of Pediatric Nephrology, Cukurova University, School of Medicine, Adana, Turkey sug: subj: Calcium Binding Proteins Nephrotic Syndrome Prognosis Apoptosis Biological Markers Biopsy Blood Proteins Chi Square Test Child Data Analysis Software Descriptive Statistics Enzyme-Linked Immunosorbent Assay Female Funding Source Kruskal-Wallis Test Male Mann-Whitney U Test ROC Curve Sensitivity and Specificity Spearman's Rank Correlation Coefficient Wilcoxon Signed Rank Test Human Child: 6-12 years Female Male ab: Annexin V has a molecular weight of 32–35 kDa and has been reported to possess anticoagulant activity, inhibition of phospholipase A2, regulation of membrane transport, proliferation and signal transduction. It is reported that urinary annexin V concentration may be an indicator of apoptosis and acute renal injury related to the urinary protein level. The aim of this study was to define the role of urinary annexin V excretion and serum annexin V concentrations as new prognostic tools and follow-up criteria in children with steroid-sensitive (SSNS) and steroid-resistant nephrotic syndrome (SRNS). Annexin V concentrations were measured in serum and 24-h urine samples in 23 SSNS patients in both relapse and remission periods of each patient and in 22 SRNS patients and 22 healthy controls. Total protein, albumin, blood urea nitrogen (BUN), creatinine, total cholesterol concentrations, and 24-h urinary excretion of protein and creatinine were also measured in each patient. In the SRNS group, median 24-h urinary annexin V levels were significantly higher than for all other groups (5,048.8 ng/g creatinine vs. 2,839.5 ng/g creatinine in SSNS relapse group; 2,500.0 ng/g creatinine in SSNS remission group, and 2,018.3 ng/g creatinine in healthy control group). No significant correlation was found between urinary protein excretion and 24-h urinary annexin V levels in all subjects. Twenty-four-hour urinary annexin V excretion may be a predictor in children with SRNS, and it may be a prognostic marker in children with NS. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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