A clinical evaluation of the Janus Web Application, a software screening tool for drug-drug interactions.
PURPOSE: To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). METHODS: One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 64; no. 12; pp. 1209 - 1215 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105597909&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105597909 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Dec2008 vid: 64 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105597909 2010135383 10.1007/s00228-008-0547-x NLM18695980 105597909 ppf: 1209 ppct: 6 formats: fmt: @attributes: type: P tig: atl: A clinical evaluation of the Janus Web Application, a software screening tool for drug-drug interactions. aug: au: Mannheimer B Ulfvarson J Eklöf S Bergqvist M von Bahr C affil: Department of Internal Medicine, Karolinska Institutet, Södersjukhuset, SE-11883, Stockholm, Sweden. buster.mannheimer@sodersjukhuset.se sug: subj: Drug Interactions Evaluation Software Adverse Drug Event Prevention and Control Pharmacy and Pharmacology Software Design Methods Human ab: PURPOSE: To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). METHODS: One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into his/her medical records provided complementing information. A clinical pharmacologist judged which potential DDIs were clinically relevant. Potentially relevant DDIs identified by the JWA were then correlated with clinically relevant DDIs. RESULTS: A total of 150 significant potential DDIs were found. Sixteen percent (24/150) were judged to be clinically relevant. CONCLUSIONS: A very small proportion of DDIs was considered clinically relevant in the specific clinical context. To optimise the software's user-friendliness, the following points need to be considered: the possibility of eliminating trivial potential DDIs, individualising drug alerts, and providing written information, accessible via a hyperlink. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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