Urinary levoglucosan as a biomarker of wood smoke exposure: observations in a mouse model and in children.
Background: Biomass smoke is an important source of particulate matter (PM), and much remains to be discovered with respect to the human health effects associated with this specific PM source. Exposure to biomass smoke can occur in one of two main categories: short-term exposures consist of periodic...
| Publicado en: | Environmental Health Perspectives Vol. 117; no. 1; pp. 74 - 80 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Jan2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105616118&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105616118 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Jan2009 vid: 117 iid: 1 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105616118 2010155735 10.1289/ehp.11378 NLM19165390 105616118 ppf: 74 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Urinary levoglucosan as a biomarker of wood smoke exposure: observations in a mouse model and in children. aug: au: Migliaccio CT Bergauff MA Palmer CP Jessop F Noonan CW Ward TJ affil: Center for Environmental Health Sciences, Biomedical and Pharmaceutical Sciences, College of Health Professions and Biomedical Sciences, 285C Skaggs Building, University of Montana, Missoula, MT 59812 USA; christopher.migliaccio@umontana.edu sug: subj: Biological Markers Urine Environmental Exposure Glucans Urine Smoke Adverse Effects Analysis of Variance Animal Studies Child Convenience Sample Data Analysis Software Descriptive Statistics Funding Source In Vivo Studies Mice Montana Particulate Matter Pearson's Correlation Coefficient Pilot Studies T-Tests Urinalysis Human Child: 6-12 years ab: Background: Biomass smoke is an important source of particulate matter (PM), and much remains to be discovered with respect to the human health effects associated with this specific PM source. Exposure to biomass smoke can occur in one of two main categories: short-term exposures consist of periodic, seasonal exposures typified by communities near forest fires or intentional agricultural burning, and long-term exposures are chronic and typified by the use of biomass materials for cooking or heating. Levoglucosan (LG), a sugar anhydride released by combustion of cellulose-containing materials, is an attractive candidate as a biomarker of wood smoke exposure. Objectives: In the present study, Balb/c mice and children were assessed for LG in urine to determine its feasibility as a biomarker. Methods: We performed urinary detection of LG by gas chromatography/mass spectrometry after intranasal instillations of LG or concentrated PM (mice) or biomass exposure (mice or humans). Results: After instillation, we recovered most of the LG within the first 4 hr. Experiments using glucose instillation proved the specificity of our system, and instillation of concentrated PM from wood smoke, ambient air, and diesel exhaust supported a connection between wood smoke and LG. In addition, LG was detected in the urine of mice exposed to wood smoke. Finally, a pilot human study proved our ability to detect LG in urine of children. Conclusions: These results demonstrate that LG in the lungs is detectable in the urine of both mice and humans and that it is a good candidate as a biomarker of exposure to biomass smoke. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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