Effects of clozapine on ethanol withdrawal syndrome in rats.
Co-morbid substance use in schizophrenic patients is common, and an important factor affects the Outcome of disease. On the other hand, drug dependence is a predictive factor for psychosis. Alcohol is one of the most frequently abused psychoactive substances and may contribute psychotic symptoms in...
| Publicado en: | Alcohol & Alcoholism Vol. 43; no. 6; pp. 619 - 626 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
Nov/Dec2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105618251&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105618251 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Nov/Dec2008 vid: 43 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105618251 2010159651 NLM18579515 105618251 ppf: 619 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effects of clozapine on ethanol withdrawal syndrome in rats. aug: au: Kayir H Uzbay T affil: Faculty of Medicine Department of Medical Pharmacology, Psychopharmacology Research Unit, Gulhane Military Medical Academy, Etlik 06018, Ankara, Turkey. sug: subj: Ethanol Adverse Effects Clozapine Therapeutic Use Substance Withdrawal Syndrome Drug Therapy Alcohol Drinking Ethanol Administration and Dosage Animals Behavior Drug Effects Behavior Clozapine Pharmacodynamics Male Motor Activity Drug Effects Motor Activity Physiology Rats Substance Withdrawal Syndrome Physiopathology Male ab: Co-morbid substance use in schizophrenic patients is common, and an important factor affects the Outcome of disease. On the other hand, drug dependence is a predictive factor for psychosis. Alcohol is one of the most frequently abused psychoactive substances and may contribute psychotic symptoms in several conditions, such as withdrawal syndrome. The present study was designed to investigate the effects of clozapine on ethanol withdrawal syndrome (EWS) in rats. Methods: Adult male Wistar rats were used in the study. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 14 days. An isocaloric liquid diet without containing ethanol was also given to control rats. Clozapine (2.5, 5 and 10 mg/kg) and its vehicle (0.1% acetic acid) were injected to rats subcutaneously at the 1.5th and 5.5th hours of ethanol withdrawal. At 2nd, 4th and 6th hours of ethanol withdrawal, rats were observed for 5 mm and withdrawal signs that included locomotor hyperactivity, agitation, tremor, tail stiffness, stereotyped behaviour and wet dog shakes were recorded or rated. Following the observations at 6th hour, subjects were tested for audiogenic seizures. Results: Clozapine significantly and dose-dependently inhibited the EWS-induced locomotor hyperactivity, wet dog shake, stereotyped behaviour, tremor and tail stiffness. However, it did not produce any significant effect on agitation and audiogenic seizures. Doses of clozapine used in the present study did not produce any significant change on locomotor activities of native rats. Conclusions: Our results suggest that clozapine had some significant beneficial effects on EWS in rats. Thus, this drug may be helpful for controlling some withdrawal signs in ethanol-dependent patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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